The Kurtzke EDSS rank stability increases 4 years after the onset of multiple sclerosis: results from the MSBase Registry

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Hughes S., Spelman T., Trojano M., Lugaresi A., Izquierdo G., Grand'Maison F., ...More

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, vol.83, no.3, pp.305-310, 2012 (SCI-Expanded) identifier identifier identifier


Background The Expanded Disability Status Scale (EDSS) is widely used to rate multiple sclerosis (MS) disability, but lack of disease duration information limits utility in assessing severity. EDSS ranking at specific disease durations was used to devise the MS Severity Score, which is gaining popularity for predicting outcomes. As this requires validation in longitudinal cohorts, we aimed to assess the utility of EDSS ranking as a predictor of 5-year outcome in the MSBase Registry.