The Kurtzke EDSS rank stability increases 4 years after the onset of multiple sclerosis: results from the MSBase Registry


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Hughes S., Spelman T., Trojano M., Lugaresi A., Izquierdo G., Grand'Maison F., ...More

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, vol.83, no.3, pp.305-310, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 83 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1136/jnnp-2011-301051
  • Title of Journal : JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
  • Page Numbers: pp.305-310

Abstract

Background The Expanded Disability Status Scale (EDSS) is widely used to rate multiple sclerosis (MS) disability, but lack of disease duration information limits utility in assessing severity. EDSS ranking at specific disease durations was used to devise the MS Severity Score, which is gaining popularity for predicting outcomes. As this requires validation in longitudinal cohorts, we aimed to assess the utility of EDSS ranking as a predictor of 5-year outcome in the MSBase Registry.