The role of rs1799889 genetic variation in Type 2 diabetes and Diabetic Nephropathy risk
Erciyes Medical Journal, vol.42, no.4, pp.441-446, 2020 (ESCI, TRDizin)
- Publication Type: Article / Article
- Volume: 42 Issue: 4
- Publication Date: 2020
- Doi Number: 10.14744/etd.2020.04378
- Journal Name: Erciyes Medical Journal
- Journal Indexes: Emerging Sources Citation Index (ESCI), Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Page Numbers: pp.441-446
- Keywords: Type-2 diabetes, diabetic nephropathy, PAI gene, rs1799889, PLASMINOGEN-ACTIVATOR INHIBITOR-1, PAI-1-675 4G/5G POLYMORPHISM, ASSOCIATION, TRAITS
- Karadeniz Technical University Affiliated: Yes
Abstract
Type 2 diabetes mellitus (T2 DM) represents a complex metabolic disease with genetic heterogeneity and world prevalence increasing recently. One of the candidate genes associated with T2 DM and diabetic nephropathy (DN) is the plasminogen activator inhibitor-1 (PAI-1) gene. The present research aimed to reveal the polymorphism frequencies of the PAI-1 gene 4G/5G and to investigate the role of this polymorphism in T2 DM and DN development.