The role of rs1799889 genetic variation in Type 2 diabetes and Diabetic Nephropathy risk


BAYRAMOĞLU A., BAYRAMOĞLU G., GÜLER H. İ.

Erciyes Medical Journal, cilt.42, ss.441-446, 2020 (Diğer Kurumların Hakemli Dergileri)

  • Cilt numarası: 42 Konu: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.14744/etd.2020.04378
  • Dergi Adı: Erciyes Medical Journal
  • Sayfa Sayıları: ss.441-446

Özet

Type 2 diabetes mellitus (T2 DM) represents a complex metabolic disease with genetic heterogeneity and world prevalence increasing recently. One of the candidate genes associated with T2 DM and diabetic nephropathy (DN) is the plasminogen activator inhibitor-1 (PAI-1) gene. The present research aimed to reveal the polymorphism frequencies of the PAI-1 gene 4G/5G and to investigate the role of this polymorphism in T2 DM and DN development.