The role of rs1799889 genetic variation in Type 2 diabetes and Diabetic Nephropathy risk


BAYRAMOĞLU A., BAYRAMOĞLU G., GÜLER H. İ.

Erciyes Medical Journal, vol.42, no.4, pp.441-446, 2020 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.14744/etd.2020.04378
  • Title of Journal : Erciyes Medical Journal
  • Page Numbers: pp.441-446
  • Keywords: Type-2 diabetes, diabetic nephropathy, PAI gene, rs1799889, PLASMINOGEN-ACTIVATOR INHIBITOR-1, PAI-1-675 4G/5G POLYMORPHISM, ASSOCIATION, TRAITS

Abstract

Type 2 diabetes mellitus (T2 DM) represents a complex metabolic disease with genetic heterogeneity and world prevalence increasing recently. One of the candidate genes associated with T2 DM and diabetic nephropathy (DN) is the plasminogen activator inhibitor-1 (PAI-1) gene. The present research aimed to reveal the polymorphism frequencies of the PAI-1 gene 4G/5G and to investigate the role of this polymorphism in T2 DM and DN development.