The role of rs1799889 genetic variation in Type 2 diabetes and Diabetic Nephropathy risk

BAYRAMOĞLU A., BAYRAMOĞLU G., GÜLER H. İ.

Erciyes Medical Journal, cilt.42, sa.4, ss.441-446, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.14744/etd.2020.04378
  • Dergi Adı: Erciyes Medical Journal
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.441-446
  • Anahtar Kelimeler: Type-2 diabetes, diabetic nephropathy, PAI gene, rs1799889, PLASMINOGEN-ACTIVATOR INHIBITOR-1, PAI-1-675 4G/5G POLYMORPHISM, ASSOCIATION, TRAITS
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Type 2 diabetes mellitus (T2 DM) represents a complex metabolic disease with genetic heterogeneity and world prevalence increasing recently. One of the candidate genes associated with T2 DM and diabetic nephropathy (DN) is the plasminogen activator inhibitor-1 (PAI-1) gene. The present research aimed to reveal the polymorphism frequencies of the PAI-1 gene 4G/5G and to investigate the role of this polymorphism in T2 DM and DN development.