Repression of oxidative phosphorylation sensitizes leukemia cell lines to cytarabine

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Yucel B., SÖNMEZ M.

HEMATOLOGY, cilt.23, sa.6, ss.330-336, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/10245332.2017.1402454
  • Dergi Adı: HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.330-336
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Objectives: Leukemia is a group of bone marrow cancers and drug resistance is one of the challenges in treatment. Caffeic acid phenethyl ester's (CAPE's) anti-proliferative and apoptotic properties have been reported in leukemia cell lines. However, CAPE's effect on drug resistance and cellular metabolism is still unknown. Thus, in this study, we aimed to explore CAPE's effect on drug resistance and oxidative phosphorylation (oxphos).