Repression of oxidative phosphorylation sensitizes leukemia cell lines to cytarabine


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Yucel B. , SÖNMEZ M.

HEMATOLOGY, vol.23, no.6, pp.330-336, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.1080/10245332.2017.1402454
  • Title of Journal : HEMATOLOGY
  • Page Numbers: pp.330-336

Abstract

Objectives: Leukemia is a group of bone marrow cancers and drug resistance is one of the challenges in treatment. Caffeic acid phenethyl ester's (CAPE's) anti-proliferative and apoptotic properties have been reported in leukemia cell lines. However, CAPE's effect on drug resistance and cellular metabolism is still unknown. Thus, in this study, we aimed to explore CAPE's effect on drug resistance and oxidative phosphorylation (oxphos).