Analysis of children with peripheral lymphadenopathy

YARIS N., Cakir M., SOEZEN E., Cobanoglu U.

CLINICAL PEDIATRICS, vol.45, no.6, pp.544-549, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 6
  • Publication Date: 2006
  • Doi Number: 10.1177/0009922806290609
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.544-549
  • Karadeniz Technical University Affiliated: Yes


In this study, the clinical and laboratory features of children with lymphadenopathy were evaluated. Over a 3-year period, 126 patients were referred to the clinic for lymphadenopathy. Twenty-eight of cases have diseases mimicking lymph adenopathy; 98 (mean age: 86 55 months) have lymphadenopathy. Localized, limited, and generalized involvement was found in 52%, 30%, and 18% of patients. The most common localization was the head and neck region. The causes of lymphadenopathy were benign diseases in 75 patients. Sixty percent were reactive lymphadenopathy, 39% were lymphadenitis. Lymphadenitis was more frequently localized and bigger than 3 cm compared with reactive adenopathy (p =.02, p =.004). Twenty-three patients have malignant diseases whose mean age was higher than others (p =.002). The enlargement of supraclavicular nodes was more likely due to malignant disease (p =.001). The risk of malignant disease was higher in patients who had generalized lymphadenopathy, lymph nodes bigger than 3 cm, hepatosplenomegaly, and high lactate dehydrogenase levels. In conclusion, this study pointed out the important clues for the differential diagnosis, which were present in the history, physical, and laboratory findings.