While health scientists define diseases as a biological disorder or loss of function, social scientists define it as a cultural phenomenon constructed through interaction between people. This research discusses the illness experiences of the families with cancer patients and the way such experience affects the biographical disruption of the family members. In this study, experiences of the relatives of cancer patients have been problematized. This problematization has been made through the concept of biographical disruption. The research was carried out by using semi-structured interview technique with the relatives of the cancer patients treated at the Karadeniz Technical University Farabi Hospital. The sample consists of 24 relatives of patients. The data obtained were interpreted by using descriptive analysis technique. As a result of the research, it was determined that the first-degree relatives of patients (eg. spouse, child) experienced more biographical disruption than the other patient relatives (eg. uncle). In addition, it has been found that factors such as treatment method, occupation, gender and status shape the illness experience.