Lack of Association Between HPGD and SMAD3 Gene Nucleotide Changes and Digital Clubbing Cases With Cancer


Calapoglu N. S. , CALAPOĞLU M., Soyoz M., Tariq M., Ahmad W., Aslan M. K.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.34, ss.226-233, 2009 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 34 Konu: 4
  • Basım Tarihi: 2009
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.226-233

Özet

Objectives: HPGD encoding an enzyme that plays an important role on regulation of prostaglandin metabolism is the only gene underlines autosomal recessive isolated congenital nail clubbing. SMAD3 gene is a member of Smad family, are possibly tumor suppressor genes because alterations of these genes occurred in various carcinomas. The aim of this study was examined HPGD and SMAD3 mutations in seven-generation family with digital clubbing and cancer.