Synthesis of oxadiazole substituted new carbazole derivatives as antioxidant and antiurease agent

European Journal of Biological Research, cilt.12, sa.2, ss.181-189, 2022 (Hakemli Dergi)

Heterocyclic compounds containing nitrogen together with an oxygen atom in their structures

are an important class of medicinal chemistry compounds due to their interesting diverse biological

applications. Some compounds including carbazole ring, which are aromatic organic compounds in tricyclic

structure, show biological activity in a wide spectrum. Oxadiazole compounds attract the attention of many

chemists thanks to their antibacterial, antitumor, anticancer, anti-viral, antimicrobial, anti-HIV,

antituberculosis and antioxidant properties. In this study, new oxadiazole substituted carbazole derivatives

were synthesized and their antioxidant, antiurease activities were investigated. 9H-carbazole is a good starting

material for the synthesis of carbazole derivatives. The antioxidant and antiurease activities of synthesized

oxadiazole substituted new carbazole derivatives were investigated. Antioxidant activity methods such as

DPPH (1,1’-diphenyl-2-picrylhydrazyl), ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)

diammonium salt) radical scavenging activities and iron reducing power capacities were used to determine

antioxidant activity of the compounds. All synthesized carbazole compounds showed antioxidant and

antiurease activity. While compound 4 shows the strongest enzyme inhibition activity, the least active

compound was found 5. All tested compounds showed higher enzyme inhibition activity than thiourea. The

highest and the lowest antioxidant activities were observed as compounds 3 and 6, respectively.