GGF2 Is Neuroprotective in a Rat Model of Cavernous Nerve Injury-Induced Erectile Dysfunction
JOURNAL OF SEXUAL MEDICINE, vol.12, no.4, pp.897-905, 2015 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 12 Issue: 4
- Publication Date: 2015
- Doi Number: 10.1111/jsm.12834
- Journal Name: JOURNAL OF SEXUAL MEDICINE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.897-905
- Keywords: Major Pelvic Ganglia, Penis, Schwann Cells, Unmyelinated Axons, Radical Prostatectomy, PERIPHERAL-NERVE, RADICAL PROSTATECTOMY, CRUSH INJURY, REGENERATION, RECOVERY, CELLS, NEUREGULIN-1, FK506, INNERVATION, PROMOTES
- Karadeniz Technical University Affiliated: No
Abstract
IntroductionErectile dysfunction is a major complication of radical prostatectomy, commonly associated with penile neuropathy. In animal models of peripheral nerve injury, glial growth factor-2 (GGF2), a member of the neuregulin family of growth factors, has neuroprotective and neurorestorative properties, but this potential has not been established after cavernous nerve (CN) injury.