GGF2 Is Neuroprotective in a Rat Model of Cavernous Nerve Injury-Induced Erectile Dysfunction

Burnett A. L., Sezen S. F., Hoke A., CAGGIANO A. O., IACI J., Lagoda G., ...More

JOURNAL OF SEXUAL MEDICINE, vol.12, no.4, pp.897-905, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1111/jsm.12834
  • Journal Name: JOURNAL OF SEXUAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.897-905
  • Keywords: Major Pelvic Ganglia, Penis, Schwann Cells, Unmyelinated Axons, Radical Prostatectomy, PERIPHERAL-NERVE, RADICAL PROSTATECTOMY, CRUSH INJURY, REGENERATION, RECOVERY, CELLS, NEUREGULIN-1, FK506, INNERVATION, PROMOTES
  • Karadeniz Technical University Affiliated: No

Abstract

IntroductionErectile dysfunction is a major complication of radical prostatectomy, commonly associated with penile neuropathy. In animal models of peripheral nerve injury, glial growth factor-2 (GGF2), a member of the neuregulin family of growth factors, has neuroprotective and neurorestorative properties, but this potential has not been established after cavernous nerve (CN) injury.