GGF2 Is Neuroprotective in a Rat Model of Cavernous Nerve Injury-Induced Erectile Dysfunction

Burnett A. L., Sezen S. F., Hoke A., CAGGIANO A. O., IACI J., Lagoda G., ...Daha Fazla

JOURNAL OF SEXUAL MEDICINE, cilt.12, sa.4, ss.897-905, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/jsm.12834
  • Dergi Adı: JOURNAL OF SEXUAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.897-905
  • Anahtar Kelimeler: Major Pelvic Ganglia, Penis, Schwann Cells, Unmyelinated Axons, Radical Prostatectomy, PERIPHERAL-NERVE, RADICAL PROSTATECTOMY, CRUSH INJURY, REGENERATION, RECOVERY, CELLS, NEUREGULIN-1, FK506, INNERVATION, PROMOTES
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

IntroductionErectile dysfunction is a major complication of radical prostatectomy, commonly associated with penile neuropathy. In animal models of peripheral nerve injury, glial growth factor-2 (GGF2), a member of the neuregulin family of growth factors, has neuroprotective and neurorestorative properties, but this potential has not been established after cavernous nerve (CN) injury.