GGF2 Is Neuroprotective in a Rat Model of Cavernous Nerve Injury-Induced Erectile Dysfunction
JOURNAL OF SEXUAL MEDICINE, cilt.12, sa.4, ss.897-905, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 4
- Basım Tarihi: 2015
- Doi Numarası: 10.1111/jsm.12834
- Dergi Adı: JOURNAL OF SEXUAL MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.897-905
- Anahtar Kelimeler: Major Pelvic Ganglia, Penis, Schwann Cells, Unmyelinated Axons, Radical Prostatectomy, PERIPHERAL-NERVE, RADICAL PROSTATECTOMY, CRUSH INJURY, REGENERATION, RECOVERY, CELLS, NEUREGULIN-1, FK506, INNERVATION, PROMOTES
- Karadeniz Teknik Üniversitesi Adresli: Hayır
Özet
IntroductionErectile dysfunction is a major complication of radical prostatectomy, commonly associated with penile neuropathy. In animal models of peripheral nerve injury, glial growth factor-2 (GGF2), a member of the neuregulin family of growth factors, has neuroprotective and neurorestorative properties, but this potential has not been established after cavernous nerve (CN) injury.