The evaluation of genotoxic potential of ornidazole, nitroimidazole, in lymphocyte culture of patients with amebiasis

Ikbal M., YILMAZ G., DOĞAN H., ALP M. Y., ÇEBİ A. H.

DRUG AND CHEMICAL TOXICOLOGY, vol.34, no.2, pp.162-166, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.3109/01480545.2010.494668
  • Journal Name: DRUG AND CHEMICAL TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.162-166
  • Keywords: Ornidazole, sister chromatid exchange, micronucleus, SINGLE-STRAND BREAKS, CHROMOSOME-ABERRATIONS, HELICOBACTER-PYLORI, MUTAGENIC ACTION, METRONIDAZOLE, TINIDAZOLE, DERIVATIVES, MICRONUCLEI
  • Karadeniz Technical University Affiliated: Yes

Abstract

The genotoxicity study of ornidazole (ONZ) was carried out on human lymphocyte chromosomes, using sister chromatid exchange (SCE) and micronucleus (MN). Thirty-two patients with Entemoeba histolitica infection who received 1000 mg/day for 10 days were included in this study. SCE and MN were measured before and after therapy. A statistically significant increase was observed in the SCE (P < 0.001) and MN frequencies (P < 0.001) after ornidazole therapy. It was concluded that ONZ has a potential geno- and cytotoxic effect in human peripheral lymphocyte cultures. For this reason, further, detailed studies are needed to elucidate the ONZ mechanism of genotoxicity and its carcinogenic potential.