The evaluation of genotoxic potential of ornidazole, nitroimidazole, in lymphocyte culture of patients with amebiasis


Ikbal M., YILMAZ G., DOĞAN H., ALP M. Y. , ÇEBİ A. H.

DRUG AND CHEMICAL TOXICOLOGY, vol.34, no.2, pp.162-166, 2011 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.3109/01480545.2010.494668
  • Journal Name: DRUG AND CHEMICAL TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.162-166
  • Keywords: Ornidazole, sister chromatid exchange, micronucleus, SINGLE-STRAND BREAKS, CHROMOSOME-ABERRATIONS, HELICOBACTER-PYLORI, MUTAGENIC ACTION, METRONIDAZOLE, TINIDAZOLE, DERIVATIVES, MICRONUCLEI

Abstract

The genotoxicity study of ornidazole (ONZ) was carried out on human lymphocyte chromosomes, using sister chromatid exchange (SCE) and micronucleus (MN). Thirty-two patients with Entemoeba histolitica infection who received 1000 mg/day for 10 days were included in this study. SCE and MN were measured before and after therapy. A statistically significant increase was observed in the SCE (P < 0.001) and MN frequencies (P < 0.001) after ornidazole therapy. It was concluded that ONZ has a potential geno- and cytotoxic effect in human peripheral lymphocyte cultures. For this reason, further, detailed studies are needed to elucidate the ONZ mechanism of genotoxicity and its carcinogenic potential.