Temporomandibular eklemde deneysel olarak oluşturulan osteoartrit tedavisinde eklem içi daidzein uygulamasının değerlendirilmesi: tavşan modeli

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Erdayandı G. E., Yılmaz O.

Turkish Association Of Oral and Maxillofacial Surgery 29th INTERNATIONAL SCIENTIFIC CONGRESS, Antalya, Turkey, 6 - 10 November 2022

  • Publication Type: Conference Paper / Summary Text
  • City: Antalya
  • Country: Turkey
  • Karadeniz Technical University Affiliated: Yes


Objective: Osteoarthritis (OA) of the temporomandibular joint (TMJ) is a chronic and degenerative disease that causes changes in the disc, synovium, cartilage and subchondral bone. There are many methods in the treatment of osteoarthritis, ranging from medical treatment to surgical treatment. Daidzein(DZ) is an isoflavone that has anti-inflammatory and
antioxidant activity. The aim of this study was to evaluate the effectiveness of DZ as a treatment for experimental TMJ OA in rabbits.
Methods: An experimental OA model was established in the right TMJ of 16 male New Zealand rabbits with monosodium iodoacetate. A rabbit was sacrificed after 4 weeks to control the OA model. Fifteen rabbits were randomly allocated into 2 groups: C (control group; intraarticular saline injection n=6), DZ (experimental group; intraarticular DZ injection n=9). DZ or saline were administered intraarticularly to the rabbits TMJ on days 1, 7, 14, and 21. After the injections, rabbits were sacrificed by decapitation under general anesthesia. Synovial fluid and blood samples were analyzed to determine the total oxidant status(TOS) and total antioxidant status(TAS). The right TMJ of the rabbits were excised for histopathological examination.
Results: In the experimental group, blood and synovial fluid TAS values were higher than the control group, and blood/synovial fluid TOS values were lower than the control group. In addition, cracks and fibrillation on the cartilage surface in the experimental group were greatly improved.
Conclusions: DZ had anti-enflammatory and antioxidant effects in a rabbit OA model. DZ may be a promising natural compound with beneficial effects in the treatment of OA.