Serum MUC3 Protein as a Novel Marker of Gestational Hypertensive Disorders

Cora A. O., GÜVEN S., Sal H., TOSUN İ., Guven E. S.

JOURNAL OF OBSTETRICS AND GYNECOLOGY OF INDIA, cilt.72, sa.6, ss.497-502, 2022 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 6
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s13224-022-01677-0
  • Dergi Adı: JOURNAL OF OBSTETRICS AND GYNECOLOGY OF INDIA
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, EMBASE
  • Sayfa Sayıları: ss.497-502
  • Anahtar Kelimeler: HELLP Syndrome, Mucoprotein 3, Preeclampsia, Pregnancy-Induced Hypertension, ELEVATED LIVER-ENZYMES, TROPHOBLAST CELLS, HUMAN PLACENTA, INVASION, EXPRESSION, PREECLAMPSIA, ESTROGEN, RECEPTOR, DIFFERENTIATION, APOPTOSIS
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background This study aimed to investigate the serum levels of mucoprotein 3 in hypertensive diseases of pregnancy. Methods In total, 60 consecutive women with gestational hypertensive diseases (gestational hypertension (n = 20), severe preeclampsia (n = 20), HELLP syndrome (n = 20)) and 20 pregnant women without any gestational hypertensive diseases were included for this prospective controlled study. Serum MUC3 protein levels were measured with commercially available ELISA kits. Results Serum MUC3 protein level was the lowest in normal pregnant women (0.1047 +/- 0.0295 ng/ml); while the severity of the disease increases, it significantly increased in severe preeclampsia (0.2700 +/- 0.0199 ng/mL) and HELLP syndrome group (0.3494 +/- 0.0455 ng/mL), but less in the gestational hypertension (0.2172 +/- 0.0354 ng/mL) group. Mean serum MUC3 protein level differences were found the least in gestational hypertension (0.1125 +/- 0.0107, p < 0.001), the most in HELLP syndrome (-0.2546 +/- 0.0107, p < 0.001) compared with the pregnant control group. Conclusion The increase in serum MUC3 protein concentration in these women supported the argument that serum MUC3 protein may be used as a marker indicating the severity of the gestational hypertensive diseases.