Microwave-Assisted Synthesis of Some New Benzimidazole Derivatives with their Antimicrobial Activity

Mentese E., Yilmaz F., Beris F. S. , BEKİRCAN O., KAHVECİ B.

CURRENT MICROWAVE CHEMISTRY, vol.2, no.1, pp.32-39, 2015 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 2 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.2174/221333560201150212104019
  • Journal Indexes: Emerging Sources Citation Index
  • Page Numbers: pp.32-39


2-(2-Chlorobenzyl)-1H-benzimidazole (2) was prepared from the reaction of o-phenylenediamine and ethylimido-o-chlorophenylacetate hydrochloride (1) under microwave irradiation. The acetate and hydrazide derivatives of 2(2- chlorobenzyl)-1H-benzimidazole (2) were synthesized respectively. Then, 2-[2-(2-chlorobenzyl)-1H-benzimidazol-1yl]-N-(2,5-dioxopyrrolidin-1-yl) acetamide (5), 5-{[2-(2-chlorobenzyl)-1H-benzimidazol-1-yl]methyl}-1,3,4-oxadiazole2-thiol (6), acetohydrazide (7a-i) and N-phenylhydrazinecarbo thioamide derivatives (8a-c) were synthesized from hydrazide derivatives. Finally, the intramolecular cyclization of N-phenylhydrazinecarbo thioamide derivatives (8a-c) gave the corresponding 1,2,4-triazole-3-thione derivatives (9a-c). The newly synthesized compounds have been tested for their antimicrobial activity against three Gram-positive and three Gram-negative bacterias.