Microwave-Assisted Synthesis of Some New Benzimidazole Derivatives with their Antimicrobial Activity

Mentese E., Yilmaz F., Beris F. S., BEKİRCAN O., KAHVECİ B.

CURRENT MICROWAVE CHEMISTRY, cilt.2, sa.1, ss.32-39, 2015 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.2174/221333560201150212104019
  • Dergi Adı: CURRENT MICROWAVE CHEMISTRY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.32-39
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

2-(2-Chlorobenzyl)-1H-benzimidazole (2) was prepared from the reaction of o-phenylenediamine and ethylimido-o-chlorophenylacetate hydrochloride (1) under microwave irradiation. The acetate and hydrazide derivatives of 2(2- chlorobenzyl)-1H-benzimidazole (2) were synthesized respectively. Then, 2-[2-(2-chlorobenzyl)-1H-benzimidazol-1yl]-N-(2,5-dioxopyrrolidin-1-yl) acetamide (5), 5-{[2-(2-chlorobenzyl)-1H-benzimidazol-1-yl]methyl}-1,3,4-oxadiazole2-thiol (6), acetohydrazide (7a-i) and N-phenylhydrazinecarbo thioamide derivatives (8a-c) were synthesized from hydrazide derivatives. Finally, the intramolecular cyclization of N-phenylhydrazinecarbo thioamide derivatives (8a-c) gave the corresponding 1,2,4-triazole-3-thione derivatives (9a-c). The newly synthesized compounds have been tested for their antimicrobial activity against three Gram-positive and three Gram-negative bacterias.