4-(4-(( 5-Amino-1,3,4-thiadiazol-2-yl)methoxy) phenyl)-1-(( 5-amino-1,3,4-thiadiazol-2-yl)methyl)-3-benzyl-1H-1,2,4-triazol-5( H)-one: Synthesis, Characterization and Computational Studies

UNLUER, Dilek; ÜNVER, YASEMİN; DUGDU, Esra; AKCAY, Hakki; SANCAK, KEMAL

doi:10.2174/1570178613666160930121719

4-(4-(( 5-Amino-1,3,4-thiadiazol-2-yl)methoxy) phenyl)-1-(( 5-amino-1,3,4-thiadiazol-2-yl)methyl)-3-benzyl-1H-1,2,4-triazol-5( H)-one: Synthesis, Characterization and Computational Studies

UNLUER D., ÜNVER Y. , DUGDU E., AKCAY H. T. , SANCAK K.

LETTERS IN ORGANIC CHEMISTRY, vol.13, no.8, pp.604-617, 2016 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 13 Issue: 8
Publication Date: 2016
Doi Number: 10.2174/1570178613666160930121719
Title of Journal : LETTERS IN ORGANIC CHEMISTRY
Page Numbers: pp.604-617

Abstract

Background: 1,2,4-triazole and its derivatives are known to have various biological activities such as antifungal, antiviral, antidepressant, antitumor, anti-inflammatory, antitubercular, antimigrain and anti-cancer. Computational chemistry plays an important role in determining structural and chemical properties of chemical compounds. There are many studies on computational studies of triazole derivatives. The aim of this study is to prepare new triazole derivative having potent of bio-active material and to investigate the computational properties.