Akademik Veri Yönetim Sistemi
Journal of Neurological Surgery, Part A: Central European Neurosurgery, cilt.85, sa.2, ss.137-141, 2022 (SCI-Expanded)
Background Increased intraocular pressure (IOP) likely secondary to an activated oculo-trigeminal reflex network is an important issue following subarachnoid hemorrhage (SAH). The relationship between the IOP and trigeminal ganglion (TGG) following experimental SAH was investigated in this study. Methods Twenty-three rabbits were used in this study. Five rabbits (n ¼ 5) were used as the control group, another 5 as the sham group (n ¼ 5), and the remaining 13 (n ¼ 13) as the study group. The study group was further divided into two groups of animals with mild (n ¼ 6) and severe (n ¼ 7) TGG degeneration. The IOP values were recorded. After 2 weeks, the animals were decapitated. The mean degenerated neuron density of TGGs was estimated by stereological methods and analyzed statistically. Results The average IOP values were 11.85, 14.12, and 21.45 mm Hg in the control (n ¼ 5), sham (n ¼ 5), and study (n ¼ 13) groups, respectively. The mean degenerated neuron density was 34, 237, and 3,165 mm3 in the control, sham, and study groups, respectively. Conclusion According to the findings of this study, the experimental SAH leads to changes in IOP by affecting the TGG. By predicting and preventing IOP elevation in the setting of SAH, our findings will shed light on secondary sequelae such as glaucoma and irreversible blindness.