In this study, Predict-Observe-Explain (POE) strategy was introduced and its effectiveness was investigated with respect to prospective science teacher opinions on an experimental activity, during the implementation and at the end of the process. The study was implemented to a group of 16 science and technology education program prospective science teachers. The research data was obtained with the analysis of worksheet and the results of experimental discussions with prospective science teachers. The developed experimental activities were conducted over the "Experimental Worksheet" including the stages of pre-experiment (prediction), experiment (observation), and post-experiment (explain) according to the POE strategy. Finally, between 10-12 min time discussion environment was prepared for 4 different groups. At the end of the study, evaluations were realized on applicability of POE and it was concluded that the developed activity according to the POE was effective and attractive in learning the science concepts.