Effect of gender on antinociceptive effect of paroxetine in hot plate test in mice

Duman E. N., Kesim M., Kadioglu M., ULKU C., Kalyoncu N. İ., Yaris E.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, vol.30, no.2, pp.292-296, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 30 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1016/j.pnpbp.2005.10.012
  • Journal Name: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.292-296
  • Keywords: antinociception, gender difference, mice, paroxetine, EXPERIMENTAL PAIN, SEX-DIFFERENCES, ANALGESIC RESPONSES, ANTIDEPRESSANTS, MORPHINE, FLUVOXAMINE, DEPRESSION, DESIPRAMINE, MECHANISMS, SERTRALINE
  • Karadeniz Technical University Affiliated: Yes

Abstract

Purpose: Many studies have reported both a gender difference in the rates of depression and its treatment by using any of the widely used antidepressant drug groups. Some studies suggest that females respond more poorly to tricyclic antidepressants than males and appear to respond better to selective serotonin reuptake inhibitors (SSRI). There is no study investigating the analgesic/antinociceptive effects of antidepressant drugs on the basis of gender difference. In this study, we aimed to investigate the antinociceptive effect of paroxetine on the basis of gender difference.