Effect of gender on antinociceptive effect of paroxetine in hot plate test in mice

Duman E. N., Kesim M., Kadioglu M., ULKU C., Kalyoncu N. İ., Yaris E.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, cilt.30, sa.2, ss.292-296, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 30 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.pnpbp.2005.10.012
  • Dergi Adı: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.292-296
  • Anahtar Kelimeler: antinociception, gender difference, mice, paroxetine, EXPERIMENTAL PAIN, SEX-DIFFERENCES, ANALGESIC RESPONSES, ANTIDEPRESSANTS, MORPHINE, FLUVOXAMINE, DEPRESSION, DESIPRAMINE, MECHANISMS, SERTRALINE
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Purpose: Many studies have reported both a gender difference in the rates of depression and its treatment by using any of the widely used antidepressant drug groups. Some studies suggest that females respond more poorly to tricyclic antidepressants than males and appear to respond better to selective serotonin reuptake inhibitors (SSRI). There is no study investigating the analgesic/antinociceptive effects of antidepressant drugs on the basis of gender difference. In this study, we aimed to investigate the antinociceptive effect of paroxetine on the basis of gender difference.