FK506 Neuroprotection After Cavernous Nerve Injury is Mediated by Thioredoxin and Glutathione Redox Systems


Lagoda G. , XIE Y., Sezen S. F. , Hurt K. J. , LIU L., Musicki B., ...More

JOURNAL OF SEXUAL MEDICINE, vol.8, no.12, pp.3325-3334, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 12
  • Publication Date: 2011
  • Doi Number: 10.1111/j.1743-6109.2011.02500.x
  • Title of Journal : JOURNAL OF SEXUAL MEDICINE
  • Page Numbers: pp.3325-3334

Abstract

Introduction. Immunophilin ligands such as FK506 (FK) preserve erectile function (EF) following cavernous nerve injury (CNI), although the precise mechanisms are unclear. We examined whether the thioredoxin (Trx) and glutathione (GSH) redox systems mediate this effect after CNI.