FK506 Neuroprotection After Cavernous Nerve Injury is Mediated by Thioredoxin and Glutathione Redox Systems

Lagoda G., XIE Y., Sezen S. F., Hurt K. J., LIU L., Musicki B., ...More

JOURNAL OF SEXUAL MEDICINE, vol.8, no.12, pp.3325-3334, 2011 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 12
  • Publication Date: 2011
  • Doi Number: 10.1111/j.1743-6109.2011.02500.x
  • Journal Name: JOURNAL OF SEXUAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3325-3334
  • Keywords: Erectile Dysfunction, Penis, Oxidative Stress, Apoptosis, Nitrosylation, Neuroprotective Effect, NITRIC-OXIDE SYNTHASE, RETINAL GANGLION-CELLS, MITOCHONDRIAL THIOREDOXIN, ERECTILE FUNCTION, IMMUNOPHILIN LIGANDS, INDUCED APOPTOSIS, S-NITROSYLATION, RECOVERY, PROTECTS, MODEL
  • Karadeniz Technical University Affiliated: No

Abstract

Introduction. Immunophilin ligands such as FK506 (FK) preserve erectile function (EF) following cavernous nerve injury (CNI), although the precise mechanisms are unclear. We examined whether the thioredoxin (Trx) and glutathione (GSH) redox systems mediate this effect after CNI.