FK506 Neuroprotection After Cavernous Nerve Injury is Mediated by Thioredoxin and Glutathione Redox Systems

Lagoda G., XIE Y., Sezen S. F., Hurt K. J., LIU L., Musicki B., ...Daha Fazla

JOURNAL OF SEXUAL MEDICINE, cilt.8, sa.12, ss.3325-3334, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 12
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1111/j.1743-6109.2011.02500.x
  • Dergi Adı: JOURNAL OF SEXUAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3325-3334
  • Anahtar Kelimeler: Erectile Dysfunction, Penis, Oxidative Stress, Apoptosis, Nitrosylation, Neuroprotective Effect, NITRIC-OXIDE SYNTHASE, RETINAL GANGLION-CELLS, MITOCHONDRIAL THIOREDOXIN, ERECTILE FUNCTION, IMMUNOPHILIN LIGANDS, INDUCED APOPTOSIS, S-NITROSYLATION, RECOVERY, PROTECTS, MODEL
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Introduction. Immunophilin ligands such as FK506 (FK) preserve erectile function (EF) following cavernous nerve injury (CNI), although the precise mechanisms are unclear. We examined whether the thioredoxin (Trx) and glutathione (GSH) redox systems mediate this effect after CNI.