FK506 Neuroprotection After Cavernous Nerve Injury is Mediated by Thioredoxin and Glutathione Redox Systems

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Atıf İçin Kopyala

Lagoda G. , XIE Y., Sezen S. F. , Hurt K. J. , LIU L., Musicki B., ...Daha Fazla

JOURNAL OF SEXUAL MEDICINE, cilt.8, ss.3325-3334, 2011 (SCI İndekslerine Giren Dergi)

• Cilt numarası: 8 Konu: 12
• Basım Tarihi: 2011
• Doi Numarası: 10.1111/j.1743-6109.2011.02500.x
• Dergi Adı: JOURNAL OF SEXUAL MEDICINE
• Sayfa Sayıları: ss.3325-3334

Özet

Introduction. Immunophilin ligands such as FK506 (FK) preserve erectile function (EF) following cavernous nerve injury (CNI), although the precise mechanisms are unclear. We examined whether the thioredoxin (Trx) and glutathione (GSH) redox systems mediate this effect after CNI.