FK506 Neuroprotection After Cavernous Nerve Injury is Mediated by Thioredoxin and Glutathione Redox Systems

Lagoda, FERİDE; XIE, YI; Sezen, Sena; Hurt, K.; LIU, Limin; Musicki, Biljana; Burnett, Arthur

doi:10.1111/j.1743-6109.2011.02500.x

FK506 Neuroprotection After Cavernous Nerve Injury is Mediated by Thioredoxin and Glutathione Redox Systems

Lagoda G. , XIE Y., Sezen S. F. , Hurt K. J. , LIU L., Musicki B., ...More

JOURNAL OF SEXUAL MEDICINE, vol.8, no.12, pp.3325-3334, 2011 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 8 Issue: 12
Publication Date: 2011
Doi Number: 10.1111/j.1743-6109.2011.02500.x
Title of Journal : JOURNAL OF SEXUAL MEDICINE
Page Numbers: pp.3325-3334

Abstract

Introduction. Immunophilin ligands such as FK506 (FK) preserve erectile function (EF) following cavernous nerve injury (CNI), although the precise mechanisms are unclear. We examined whether the thioredoxin (Trx) and glutathione (GSH) redox systems mediate this effect after CNI.