Akademik Veri Yönetim Sistemi
HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI, sa.3, ss.141-148, 2024 (ESCI)
Aim: In this study, we aimed to investigate the role of malondialdehyde (MDA) in the pathophysiology of periodontitis by examining serum and salivary MDA levels in patients with advanced periodontitis and healthy individuals according to the periodontal disease classification revised in the workshop held by the American Association of Chartered Epidemiologists and the European Federation in 2017. Methods: The study was designed as a cross-sectional study, and a total of 37 patients who applied to Karadeniz Technical University Faculty of Dentistry, Department of Periodontology, in 2022 for periodontal disorders or controls were included. A total of 37 individuals, aged 25-48 years, with stage III grade C periodontitis (Group 1; 13 patients), stage IV grade C periodontitis (Group 2; 12 patients), and a periodontally healthy group (Group 3; 12 individuals) were included in the study. After the demographic characteristics and body mass index (BMI) data were obtained, the clinical periodontal parameters and serum and saliva MDA values of the individuals were measured. All the obtained data were statistically analyzed. Results: Although BMI was lower and education level was higher in the controls (p<0.034), other demographic characteristics did not differ between the groups. When the clinical periodontal parameters were examined, the lowest values were observed in the controls, whereas the highest values were observed in stage IV. The difference between all three groups was statistically significant (p=0.000). Although serum MDA levels did not differ between the groups, the highest MDA level was observed in stage III, and the lowest MDA level was observed in the controls. In addition, salivary MDA levels did not differ between the groups, with the highest MDA level observed in stage III and the lowest MDA level observed in stage IV. Conclusion: The findings of our study showed that systemic and local lipid peroxidation levels increased/decreased in individuals with advanced periodontitis compared with the periodontal healthy group, but this change was not statistically significant. Our findings suggest that different oxidative stress mechanisms may also be involved in advanced periodontitis.