Marine-Lenhart syndrome in a young girl

Sen Y., Cimbek E. A., Yuca S. A., Gedik G. K., Sari O.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.27, no.1-2, pp.189-191, 2014 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 1-2
  • Publication Date: 2014
  • Doi Number: 10.1515/jpem-2013-0302
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.189-191
  • Keywords: children, Graves' disease, nodule, GRAVES-DISEASE, FUNCTIONING NODULES, RADIOIODINE
  • Karadeniz Technical University Affiliated: No


Graves' disease is the most common reason of hyperthyroidism in children. Graves' disease with accompanying functioning nodules is defined as Marine-Lenhart syndrome. This syndrome has not been described in children before. Here, a 15-year-old girl with Graves' disease and a coexisting cold nodule is presented. A thyroid scan showed diffuse uptake of Tc-99m pertechnatate in both lobes and decreased uptake in accordance with the left lobe nodule. The nodule was histologically diagnosed as benign. The patient was diagnosed with type 1 diabetes mellitus and polyglandular autoimmune syndrome during clinical follow-up. The differential diagnoses of Graves' disease with coexisting nodules should include the Marine-Lenhart syndrome. Treatment options should be determined taking this rare condition into account.