Protoporphyrin IX-loaded magnetoliposomes as a potential drug delivery system for photodynamic therapy: Fabrication, characterization and in vitro study

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Basoglu H., Bilgin M. D., Demir M. M.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, vol.13, pp.81-90, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2016
  • Doi Number: 10.1016/j.pdpdt.2015.12.010
  • Journal Name: PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.81-90
  • Keywords: Protoporphyrin IX, Magnetoliposomes, Iron oxide nanoparticles, Photodynamic therapy, MCF-7 cells, LIPOSOMES, NANOPARTICLES, PORPHYRIN, PHOTOSENSITIVITY, BEHAVIOR, TUMOR
  • Karadeniz Technical University Affiliated: No

Abstract

Background: Protoporphyrin IX (PpIX) is a well-known photosensitizer that has great potential for use in photodynamic therapy (PDT). However, aggregation behavior of PpIX in neutral water makes it inappropriate for physiological studies. PpIX-loaded magnetoliposomes (MLs) were fabricated to increase PpIX biocompatibility. PpIX-loaded ML physical properties were characterized, and PpIX-loaded ML drug release behavior was investigated under the influence of an external magnetic field and heat. Toxicity and photodynamic effects of the complex were also examined using in vitro experiments with MCF-7 human breast cancer cells.