Protoporphyrin IX-loaded magnetoliposomes as a potential drug delivery system for photodynamic therapy: Fabrication, characterization and in vitro study

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Basoglu H., Bilgin M. D., Demir M. M.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, cilt.13, ss.81-90, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.pdpdt.2015.12.010
  • Dergi Adı: PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.81-90
  • Anahtar Kelimeler: Protoporphyrin IX, Magnetoliposomes, Iron oxide nanoparticles, Photodynamic therapy, MCF-7 cells, LIPOSOMES, NANOPARTICLES, PORPHYRIN, PHOTOSENSITIVITY, BEHAVIOR, TUMOR
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Background: Protoporphyrin IX (PpIX) is a well-known photosensitizer that has great potential for use in photodynamic therapy (PDT). However, aggregation behavior of PpIX in neutral water makes it inappropriate for physiological studies. PpIX-loaded magnetoliposomes (MLs) were fabricated to increase PpIX biocompatibility. PpIX-loaded ML physical properties were characterized, and PpIX-loaded ML drug release behavior was investigated under the influence of an external magnetic field and heat. Toxicity and photodynamic effects of the complex were also examined using in vitro experiments with MCF-7 human breast cancer cells.