Effect of human amniotic fluid on bone healing

Karacal N., Kosucu P., Cobanglu U., KUTLU N.

JOURNAL OF SURGICAL RESEARCH, cilt.129, sa.2, ss.283-287, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 129 Sayı: 2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.jss.2005.03.026
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.283-287
  • Anahtar Kelimeler: human amniotic fluid, bone healing, hyaluronic acid, GROWTH-FACTOR-BETA, ACID-STIMULATING ACTIVITY, FETAL WOUND FLUID, HYALURONIC-ACID, EXTRACELLULAR-MATRIX, SODIUM HYALURONATE, DEFECTS, ENHANCEMENT, SULFATE, REPAIR
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background. Bone healing continues to pose challenges for researchers and clinicians working in the field of plastic surgery. Complete bone regeneration cannot be obtained in critical size osseous defects without the application of osteogenic or osteoinductive bone material. In this study, we hypothesized that because extracellular matrix components are known to play a major role in the first steps of healing during bone or injury healing and because hyaluronic acid as chondroitin sulfate is recognized as an osteogenic compound without osteoinductive activity, human amniotic fluid, which contains high concentrations of hyaluronic acid, gyaluronic acid -stimulating activator, and other factors, might accelerate bone healing when applied subperiosteally to rabbit calvarial defects.