Effect of human amniotic fluid on bone healing

Karacal N., Kosucu P., Cobanglu U., KUTLU N.

JOURNAL OF SURGICAL RESEARCH, vol.129, no.2, pp.283-287, 2005 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 129 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1016/j.jss.2005.03.026
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.283-287


Background. Bone healing continues to pose challenges for researchers and clinicians working in the field of plastic surgery. Complete bone regeneration cannot be obtained in critical size osseous defects without the application of osteogenic or osteoinductive bone material. In this study, we hypothesized that because extracellular matrix components are known to play a major role in the first steps of healing during bone or injury healing and because hyaluronic acid as chondroitin sulfate is recognized as an osteogenic compound without osteoinductive activity, human amniotic fluid, which contains high concentrations of hyaluronic acid, gyaluronic acid -stimulating activator, and other factors, might accelerate bone healing when applied subperiosteally to rabbit calvarial defects.