Synthesis of some new Methoxy Bridged Benzimidazolyl-Substituted phthalocyanines as potent inhibitors of urease

DEMİRBAŞ Ü., Mentese E., Sokmen B. B., Bayrak R., Akcay H. T.

JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol.873, pp.86-90, 2018 (SCI-Expanded) identifier identifier


In this study, the novel peripherally 4-[(2-methyl-1H-benzimidazol-1-yl)methoxy] substituted Zn(II) (3) Cu(II) (4), Co(II) (5) phthalocyanines were prepared and their structures were characterized spectro-scopically. The light absorption behaviors of the synthesized compounds (3-6) were studied by UV-Vis spectroscopy in the different concentration and different solvents were studied also. In addition, the urease inhibition activities of the synthesized compounds were also investigated. Among the synthesized molecules, compound 5 showed the best inhibitory effect against jack bean urease with IC50 values of 0.0034 +/- 0.0010 mu M. (C) 2018 Elsevier B.V. All rights reserved.