Synthesis of some new Methoxy Bridged Benzimidazolyl-Substituted phthalocyanines as potent inhibitors of urease

DEMİRBAŞ, ÜMİT; Mentese, Emre; Sokmen, Bahar; Bayrak, Riza; Akcay, Hakki

doi:10.1016/j.jorganchem.2018.08.001

Synthesis of some new Methoxy Bridged Benzimidazolyl-Substituted phthalocyanines as potent inhibitors of urease

Atıf İçin Kopyala

DEMİRBAŞ Ü., Mentese E., Sokmen B. B., Bayrak R., Akcay H. T.

JOURNAL OF ORGANOMETALLIC CHEMISTRY, cilt.873, ss.86-90, 2018 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 873
Basım Tarihi: 2018
Doi Numarası: 10.1016/j.jorganchem.2018.08.001
Dergi Adı: JOURNAL OF ORGANOMETALLIC CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.86-90
Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

In this study, the novel peripherally 4-[(2-methyl-1H-benzimidazol-1-yl)methoxy] substituted Zn(II) (3) Cu(II) (4), Co(II) (5) phthalocyanines were prepared and their structures were characterized spectro-scopically. The light absorption behaviors of the synthesized compounds (3-6) were studied by UV-Vis spectroscopy in the different concentration and different solvents were studied also. In addition, the urease inhibition activities of the synthesized compounds were also investigated. Among the synthesized molecules, compound 5 showed the best inhibitory effect against jack bean urease with IC50 values of 0.0034 +/- 0.0010 mu M. (C) 2018 Elsevier B.V. All rights reserved.