Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo


Ulukaya E., ARI F., Dimas K., Ikitimur E. I., Guney E., YILMAZ V. T.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.46, no.10, pp.4957-4963, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 10
  • Publication Date: 2011
  • Doi Number: 10.1016/j.ejmech.2011.07.055
  • Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4957-4963
  • Keywords: Palladium(II) complex, Breast cancer, Cytotoxicity, Apoptosis, Treatment, PLATINUM(II) COMPLEXES, BIOLOGICAL EVALUATION, CYTOTOXIC ACTIVITY, PD(II), PT(II), ASSAY, MTT
  • Karadeniz Technical University Affiliated: No

Abstract

Anti-cancer effects of a newly-synthesized palladium(II) complex, [Pd(sac)(terpy)](sac)center dot 4H(2)O (sac = saccharinate, and terpy = 2,2':6',2 ''-terpyridine), were tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. The Pd complex had a strong anti-growth effect in a dose- and time-dependent manner in vitro. This effect was also confirmed by the experiment performed on Balb/c mice in vivo. The IC50 values were 0.09 mu M for MDA-MB-231 and 3.05 mu M for MCF-7. It was also very effective in disrupting the formation of MDA-MB-231 tubules on matrigel, indicative of a putative anti-invasive activity. It induced apoptosis via the cell death genes of DR4 and DR5. In conclusion, this newly-synthesized Pd (II) complex represents a potentially active novel drug for the breast cancer treatment. (C) 2011 Elsevier Masson SAS. All rights reserved.