Akademik Veri Yönetim Sistemi
DALTON TRANSACTIONS, cilt.55, sa.18, ss.7184-7196, 2026 (SCI-Expanded, Scopus)
Type 2 diabetes mellitus (DM) is a chronic metabolic disorder with a rapidly increasing global prevalence, highlighting the need for safer and more effective therapeutic strategies. In this study, a series of axially disubstituted silicon(iv) phthalocyanines bearing morpholine functional groups and their water-soluble derivatives were synthesized, structurally characterized, and evaluated for their antidiabetic potential. The synthesized compounds were characterized by FT-IR, H-1 and C-13 NMR, UV-Vis spectroscopy, and mass spectrometry. The in vitro antidiabetic activity of the compounds was evaluated through alpha-glycosidase and alpha-amylase inhibition assays. The non-ionic silicon(iv) phthalocyanine derivatives MT-C3-H-Si and MT-C3-D-Si exhibited strong alpha-glucosidase inhibitory activity with IC50 values of 16.02 +/- 0.94 mu M and 44.14 +/- 4.06 mu M, respectively, showing higher potency than the standard inhibitor acarbose (IC50 = 60.51 +/- 4.66 mu M). In contrast, the water-soluble derivatives MT-C3-H-SiQ and MT-C3-D-SiQ displayed lower inhibitory activity (IC50 = 68.80 +/- 5.12 mu M and >100 mu M, respectively), indicating that increased hydrophilicity does not necessarily enhance enzyme inhibition. All compounds exhibited weak alpha-amylase inhibition (IC50 > 100 mu M) compared with acarbose (IC50 = 25.29 +/- 3.50 mu M). Kinetic studies revealed that MT-C3-H-Si and MT-C3-D-Si inhibit alpha-glycosidase via a non-competitive mechanism, with K-i values of 9.45 +/- 1.45 mu M and 29.06 +/- 5.16 mu M, respectively. This is characterized by decreased V-max values without significant changes in K-m, suggesting interaction with allosteric regions of the enzyme. Overall, these findings highlight axially disubstituted silicon(iv) phthalocyanines as promising molecular scaffolds and contribute valuable insight into the limited literature on their antidiabetic enzyme inhibition properties.