Assessment of oxidative stress parameters of brain-derived neurotrophic factor heterozygous mice in acute stress model

Hacioglu G., ŞENTÜRK A., INCE I., ALVER A.

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol.19, no.4, pp.388-393, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2016
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.388-393
  • Keywords: Brain-derived neurotrophic - factor, Cerebral cortex, Physiological stress, Reactive oxygen species, VISUAL-CORTEX, BDNF-LEVELS, MALONALDEHYDE, ACTIVATION, DEPRESSION, DISORDERS, RECEPTORS, DISEASES, TISSUES
  • Karadeniz Technical University Affiliated: Yes


Objective(s): Exposing to stress may be associated with increased production of reactive oxygen species (ROS). Therefore, high level of oxidative stress may eventually give rise to accumulation of oxidative damage and development of numerous neurodegenerative diseases. It has been presented that brain-derived neurotrophic factor (BDNF) supports neurons against various neurodegenerative conditions. Lately, there has been growing evidence that changes in the cerebral neurotrophic support and especially in the BDNF expression and its engagement with ROS might be important in various disorders and neurodegenerative diseases. Hence, we aimed to investigate protective effects of BDNF against stress-induced oxidative damage.