Sex difference in susceptibility to picrotoxin-induced seizures in rats following octreotide


Tan M., Kalyoncu N. İ. , Tan U.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, vol.112, no.8, pp.903-911, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 112 Issue: 8
  • Publication Date: 2002
  • Doi Number: 10.1080/00207450290025914
  • Title of Journal : INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Page Numbers: pp.903-911
  • Keywords: epilepsy, octreotide, picrotoxin, rat, sex difference, somatostatin, NEUROPEPTIDE-Y, BRAIN SOMATOSTATIN, NEURONS

Abstract

It was previously reported that females with proestrous are more susceptible to picrotoxin-induced epileptic seizures than males, provided that the estrous cycle is taken into consideration (Tan & Tall, 2001). The sex difference in susceptibility to picrotoxin-induced seizures was reconsidered in the present study using rats with a previous octreotide (a stable somatostatin analogue) injection, as somatostatin is known to be involved in epileptic, phenomena. Contrary to rats without octreotide, males were more susceptible to picrotoxin-induced seizures than females. Statistical analysis indicated that only males showed decreased latencies to seizures and increased seizure frequencies following Octreotide; females were not affected by this experimental procedure. It was suggested that as a GABA antagonist, somatostatin may contribute to the occurrence of epileptic discharges in nervous system, creating a sex difference to epileptic seizures. These results may have implications for understanding the epileptic mechanisms, with possible therapeutic consequences.