Sex difference in susceptibility to picrotoxin-induced seizures in rats following octreotide

Tan M., Kalyoncu N. İ., Tan U.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.112, sa.8, ss.903-911, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 112 Sayı: 8
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1080/00207450290025914
  • Dergi Adı: INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.903-911
  • Anahtar Kelimeler: epilepsy, octreotide, picrotoxin, rat, sex difference, somatostatin, NEUROPEPTIDE-Y, BRAIN SOMATOSTATIN, NEURONS
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

It was previously reported that females with proestrous are more susceptible to picrotoxin-induced epileptic seizures than males, provided that the estrous cycle is taken into consideration (Tan & Tall, 2001). The sex difference in susceptibility to picrotoxin-induced seizures was reconsidered in the present study using rats with a previous octreotide (a stable somatostatin analogue) injection, as somatostatin is known to be involved in epileptic, phenomena. Contrary to rats without octreotide, males were more susceptible to picrotoxin-induced seizures than females. Statistical analysis indicated that only males showed decreased latencies to seizures and increased seizure frequencies following Octreotide; females were not affected by this experimental procedure. It was suggested that as a GABA antagonist, somatostatin may contribute to the occurrence of epileptic discharges in nervous system, creating a sex difference to epileptic seizures. These results may have implications for understanding the epileptic mechanisms, with possible therapeutic consequences.