A convenient synthesis of 3,6-disubstituted-1,4-dihydro-[1,2,4,5] tetrazines and preparation of new acetic acid derivatives containing 5-oxo-4-phenylamino-4,5-dihydro-[1,2,4]triazole


Demirbas A.

TURKISH JOURNAL OF CHEMISTRY, cilt.28, ss.311-323, 2004 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 28 Konu: 3
  • Basım Tarihi: 2004
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.311-323

Özet

series of compounds 8a-e, was synthesized by condensation of compounds 7a-e with ethyl bromoacetate. The treatment of compounds 8a-e with hydrazine hydrate afforded the corresponding hydrazide derivatives (9a-e). Subsequently, compounds 9a-e were converted to alkylidene hydrazides (10a-e). Moreover, upon heating in the presence of carboxylic acids, compounds 9a-e unexpectedly gave 1,4dihydro-(1,2,4,5)tetrazine derivatives (11a-e).

A series of compounds 8a-e, was synthesized by condensation of compounds 7a-e with ethyl bromoacetate. The treatment of compounds 8a-e with hydrazine hydrate afforded the corresponding hydrazide derivatives (9a-e). Subsequently, compounds 9a-e were converted to alkylidene hydrazides (10a-e). Moreover, upon heating in the presence of carboxylic acids, compounds 9a-e unexpectedly gave 1,4- dihydro-[1,2,4,5]tetrazine derivatives (11a-e).