A convenient synthesis of 3,6-disubstituted-1,4-dihydro-[1,2,4,5] tetrazines and preparation of new acetic acid derivatives containing 5-oxo-4-phenylamino-4,5-dihydro-[1,2,4]triazole

Demirbas A.

TURKISH JOURNAL OF CHEMISTRY, vol.28, no.3, pp.311-323, 2004 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 3
  • Publication Date: 2004
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.311-323
  • Karadeniz Technical University Affiliated: Yes

Abstract

A series of compounds 8a-e, was synthesized by condensation of compounds 7a-e with ethyl bromoacetate. The treatment of compounds 8a-e with hydrazine hydrate afforded the corresponding hydrazide derivatives (9a-e). Subsequently, compounds 9a-e were converted to alkylidene hydrazides (10a-e). Moreover, upon heating in the presence of carboxylic acids, compounds 9a-e unexpectedly gave 1,4- dihydro-[1,2,4,5]tetrazine derivatives (11a-e).

series of compounds 8a-e, was synthesized by condensation of compounds 7a-e with ethyl bromoacetate. The treatment of compounds 8a-e with hydrazine hydrate afforded the corresponding hydrazide derivatives (9a-e). Subsequently, compounds 9a-e were converted to alkylidene hydrazides (10a-e). Moreover, upon heating in the presence of carboxylic acids, compounds 9a-e unexpectedly gave 1,4dihydro-(1,2,4,5)tetrazine derivatives (11a-e).