Effects of intravitreous sodium hydrosulfide on intraocular pressure and retinopathy in ocular hypertensive rats

Ozer M. A., Erisgin Z., Ozen S., Tekelioglu Y., Takir S.

BIOTECHNIC & HISTOCHEMISTRY, vol.93, no.1, pp.8-14, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 93 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1080/10520295.2017.1373199
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.8-14
  • Keywords: glaucoma, histopathology, hydrogen sulfide, intraocular pressure, intravitreous injection, laser photocoagulation, vitreous, CYSTATHIONINE BETA-SYNTHASE, HYDROGEN-SULFIDE, OXIDATIVE STRESS, GLAUCOMA, RETINA
  • Karadeniz Technical University Affiliated: Yes


We investigated the possible neuroprotectant and intraocular pressure (TOP) lowering effects of intravitreous injection of sodium hydrosulfide (NaSH) in a rodent model of experimental glaucoma. Glaucoma currently is treated by controlling TOP using medications and/or surgery. These methods are not entirely adequate for all patients. We divided 24 rats into three groups. For the control group, the right eye was treated with intravitreous saline. For the glaucoma group, ocular hypertension was induced by photocoagulating three episcleral veins and the limbal plexus of the right eye using an argon laser, then saline was injected into the vitreous of these eyes during the third week. For the NaSH group, rats were treated with intravenous NaSH 3 weeks after photocoagulation. IOP was measured each week during the 6 week experimental period. Coagulating the episcleral veins rapidly increased the IOP of rat eyes. Intravitreous injection of NaSH significantly reduced IOP. Intravitreous NaSH prevented degeneration of the retina and decreased the number of apoptotic cells. Intravitreous NaSH appeared to reduce IOP and to prevent IOP induced retinopathy in rats.