Anodic behaviour of fulvestrant and its voltammetric determination in pharmaceuticals and human serum on highly boron-doped diamond electrode using differential pulse adsorptive stripping voltammetry

Dogan-Topal B., KUL D., Ozkan S. A., Uslu B.

JOURNAL OF APPLIED ELECTROCHEMISTRY, cilt.41, sa.11, ss.1253-1260, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 41 Sayı: 11
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s10800-011-0355-3
  • Dergi Adı: JOURNAL OF APPLIED ELECTROCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1253-1260
  • Anahtar Kelimeler: Fulvestrant, Drug analysis, Human serum, Boron-doped diamond electrode, Adsorptive stripping voltammetry, ADVANCED BREAST-CANCER
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

The electrochemical oxidation of fulvestrant was made on highly boron-doped diamond electrode using differential pulse adsorptive stripping voltammetry. The highest current intensities were obtained by applying +1.10 V during 150 s for boron-doped diamond electrode. For boron-doped diamond electrode, linear responses were obtained for the concentrations between 1 x 10(-6) and 8 x 10(-5) M in standard samples and between 1 x 10(-6) and 4 x 10(-5) M in serum samples. The repeatability of the method was 0.55 RSD% for differential pulse adsorptive stripping voltammetry. The analytical values of the method are demonstrated by quantitative determination of fulvestrant in pharmaceutical formulations and human serum, without the need for separation or complex sample preparation, since there was no interference from the excipients and endogenous substances. Selectivity, reproducibility, and accuracy of the developed methods were demonstrated by recovery studies.