A new treatment with bleomycin for complicated cutaneous hemangioma in children

Sarihan H., Mocan H., Yildiz K., Abes M., Akyazici R.

EUROPEAN JOURNAL OF PEDIATRIC SURGERY, vol.7, no.3, pp.158-162, 1997 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 3
  • Publication Date: 1997
  • Doi Number: 10.1055/s-2008-1071080
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.158-162
  • Karadeniz Technical University Affiliated: No


Cutaneous hemangiomas are the most common tumors of infants and children. Although they frequently resolve spontaneously, approximately 5 % produce complications such as bleeding, infection, consumption coagulopathy and unesthetic appearance. Various methods of treatment are described for these complicated hemangiomas. We used a new type of treatment for complicated cutaneous hemangiomas as intralesional bleomycin (BLM) injection, for the first time in the literature. This agent produced extensive fibrosis and spontaneous resolution of hemangiomas. Fourteen patients with complicated hemangiomas (twelve capillary and two cavernous) have been treated with this method during a three-years period. Of these fourteen patients, five had bleeding, three had infection, one had ulceration, and five had unesthetic appearence and continued rapid growth.