The purpose of this study was to compare in vitro bonding effectiveness of Vertise Flow (VF), a new self-adhering flowable composite (FC), and Ultimate Flow (UF), a conventional FC, to BioAggregate (BA), and to investigate whether the use of self-etch or etch-and-rinse adhesive improved the bond strength of VF to BA. Shear bond strengths of FC to BA were measured for this reason. Data were analyzed using Wilcoxon and Mann-Whitney U-tests (p=0.05). There were significant differences of bond strengths after 24- and 72-h (p<0.05, p<0.001). After 72-h, self-adhering FC may be used successfully with BA and no other adhesive, as an alternative to the combined use of conventional FC and self-etch adhesives. The use of etch-and-rinse adhesives with self-adhering FC may improve adhesion to BA.