Comparison of the protective effect of dipyridamole and acetylsalicylic acid on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury

KARAGÜZEL E., KUTLU O., YULUĞ E., Mungan S., KAZAZ İ. O., TOK D. S., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.47, no.9, pp.1716-1723, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 9
  • Publication Date: 2012
  • Doi Number: 10.1016/j.jpedsurg.2012.01.078
  • Journal Name: JOURNAL OF PEDIATRIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1716-1723
  • Keywords: Dipyridamole, Acetylsalicylic acid, Testicular torsion, Rats, Reperfusion injury, CELL-SPECIFIC APOPTOSIS, OXIDATIVE STRESS, SUPEROXIDE ANION, SPERMATIC CORD, VITAMIN-E, TORSION, ASPIRIN, EXPRESSION, BRAIN, PATHOPHYSIOLOGY
  • Karadeniz Technical University Affiliated: Yes

Abstract

Purpose: Ischemia reperfusion injury arising from testicular torsion results in a loss of spermatogenesis and a significant increase in germ cell apoptosis. We investigated the effects of dipyridamole and acetylsalicylic acid (ASA), 2 well-known platelet inhibitors, on testicular ischemia reperfusion injury.