Cuprizone-induced demyelination in Wistar rats; electrophysiological and histological assessment

Basoglu H., Boylu N. T., KÖSE H.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.17, sa.20, ss.2711-2717, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 20
  • Basım Tarihi: 2013
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2711-2717
  • Anahtar Kelimeler: Cuprizone, Multiple sclerosis, Nerve conduction velocity, Spinal cord, Wistar, CENTRAL-NERVOUS-SYSTEM, MULTIPLE-SCLEROSIS, REMYELINATION, BRAIN, MODEL, EXPRESSION
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

OBJECTIVES: Multiple Sclerosis (MS) is a disease that affects the Central Nervous System by destructing myelin shield and also can affects the peripheral nervous system. Demyelination is acquired characteristics disease and appears with the degeneration of myelin which protects the axons. Cuprizone (CPZ) model is a toxic demyelination model. The purpose of this study was to develop an MS model by cuprizone exposure toWistar rats.