Cuprizone-induced demyelination in Wistar rats; electrophysiological and histological assessment


Basoglu H., Boylu N. T., KÖSE H.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.17, no.20, pp.2711-2717, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 20
  • Publication Date: 2013
  • Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2711-2717
  • Keywords: Cuprizone, Multiple sclerosis, Nerve conduction velocity, Spinal cord, Wistar, CENTRAL-NERVOUS-SYSTEM, MULTIPLE-SCLEROSIS, REMYELINATION, BRAIN, MODEL, EXPRESSION
  • Karadeniz Technical University Affiliated: No

Abstract

OBJECTIVES: Multiple Sclerosis (MS) is a disease that affects the Central Nervous System by destructing myelin shield and also can affects the peripheral nervous system. Demyelination is acquired characteristics disease and appears with the degeneration of myelin which protects the axons. Cuprizone (CPZ) model is a toxic demyelination model. The purpose of this study was to develop an MS model by cuprizone exposure toWistar rats.