Synthesis and characterizations of some new tetra-thiosemicarbazones and their cyclization reactions; tetra-4-methyl-5-etoxycarbonyl-2,3-dihydro-1,3-thiazole and tetra-2-acetylamino-4-acetyl-4,5-dihydro-1,3,4-thiodiazole derivatives

Er M., Uenver Y., SANCAK K., DUEGDUE E.

ARKIVOC, pp.99-120, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2008
  • Doi Number: 10.3998/ark.5550190.0009.f12
  • Journal Name: ARKIVOC
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.99-120
  • Karadeniz Technical University Affiliated: Yes


Tetra-aldehyde and ketone derivatives (2a-d) which were used to obtain tetra thiosemicarbazone compounds 3a-h were synthesized via the reaction of Ethene-1,1,2,2,-tetra-yl-tetra-methylene-tetra-bromide (1) with aldehydes and ketons. Then, tetra-thiosemicarbazone compounds 3a-h were obtained from the reactions of tetra-aldehyde and keton derivatives (2a-d) with thiosemicarbazite and 4-methyl thiosemicarbazite, respectively. In the same way, tetra-4-methyl-5-ethoxycarbonyl-2,3-dihydro-1,3-thiazole compounds 4a-h were synthesized via the reaction of tetra-thiosemicarbazone compounds 3a-h with ethyl-2-chloroacetoacetate. Then, tetra-thiosemicarbazone compounds 3a-h were reacted with acetic anhydride, and yielded tetra-2-acetyl-amino-4-acetyl-4,5-dihydro-1,3,4-thiodiazol compounds (5a,b,c,e,f,g). They were characterized by elemental analysis, infrared, H-1 and C-13-NMR, mass spectroscopy. Then, the microbial features of all compounds were studied by the known method.