New Chalcone Derivatives with Schiff Base-Thiophene: Synthesis, Biological Activity, and Molecular Docking Studies

Unver Y., Tuluk M., Kahriman N., Emirik M., Bektas E., Direkel S.

RUSSIAN JOURNAL OF GENERAL CHEMISTRY, cilt.89, sa.4, ss.794-799, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1134/s107036321904025x
  • Dergi Adı: RUSSIAN JOURNAL OF GENERAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.794-799
  • Anahtar Kelimeler: chalcone, Schiff base, thiophene, molecular docking, antileishmanial and antimicrobial activity
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

New thiophene chalcones 3, 6 and thiophene Schiff base-chalcone derivatives 4a-4d, 7a-7d are synthesized. Structures of the compounds are confirmed by H-1 and C-13 NMR, and IR spectra. According to antimicrobial and antileishmanial tests, the compounds 4c-7c demonstrate efficient antileishmanial and antimicrobial activities. Molecular docking studies based on Maestro Molecular Modeling indicate 4c and 7c to be the most potent compounds that are characterized by the least docking score,-10.674 and-10.989 kcal/mol, respectively.