New Chalcone Derivatives with Schiff Base-Thiophene: Synthesis, Biological Activity, and Molecular Docking Studies
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, cilt.89, sa.4, ss.794-799, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 89 Sayı: 4
- Basım Tarihi: 2019
- Doi Numarası: 10.1134/s107036321904025x
- Dergi Adı: RUSSIAN JOURNAL OF GENERAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.794-799
- Anahtar Kelimeler: chalcone, Schiff base, thiophene, molecular docking, antileishmanial and antimicrobial activity
- Karadeniz Teknik Üniversitesi Adresli: Evet
Özet
New thiophene chalcones 3, 6 and thiophene Schiff base-chalcone derivatives 4a-4d, 7a-7d are synthesized. Structures of the compounds are confirmed by H-1 and C-13 NMR, and IR spectra. According to antimicrobial and antileishmanial tests, the compounds 4c-7c demonstrate efficient antileishmanial and antimicrobial activities. Molecular docking studies based on Maestro Molecular Modeling indicate 4c and 7c to be the most potent compounds that are characterized by the least docking score,-10.674 and-10.989 kcal/mol, respectively.