Microencapsulation of parathyroid cells via electric field and non-surgical transplantation approach.

Karabıyık Acar Ö., Başoğlu H., Keğin M., Nozhatzadeh G. D., Hacıhasanoğlu E., Tuncer A. A., ...Daha Fazla

Journal of endocrinological investigation, cilt.46, sa.11, ss.2257-2267, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 11
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s40618-023-02075-7
  • Dergi Adı: Journal of endocrinological investigation
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.2257-2267
  • Anahtar Kelimeler: Electric field, Microbead, Transplantation, Hypoparathyroidism, Parathyroid cell encapsulation, HYPOPARATHYROIDISM, MICROCAPSULES, ENCAPSULATION, SIZE, EPIDEMIOLOGY, TISSUE, MANAGEMENT, STATEMENT, DIAGNOSIS, SMALLER
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Purpose Hypoparathyroidism is a rare disease with low PTH, mostly seen as a consequence of neck surgery. Current management is the prescription of calcium and vitamin D, but the definitive treatment is parathyroid allotransplantation, which frequently triggers an immune response, thus cannot achieve the expected success. To overcome this problem, encapsulation of allogeneic cells is the most promising method. By optimizing the standard alginate cell encapsulation technique with parathyroid cells under high-voltage application, the authors reduced the size of parathyroid-encapsulated beads and evaluated these samples in vitro and in vivo.