Epilepsy may cause increased pain sensitivity: Evidence from absence epileptic WAG/Rij rats


VELİOĞLU S. , GEDİKLİ Ö. , Yildirim M., AYAR A.

EPILEPSY & BEHAVIOR, cilt.75, ss.146-150, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 75
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.yebeh.2017.07.007
  • Dergi Adı: EPILEPSY & BEHAVIOR
  • Sayfa Sayıları: ss.146-150

Özet

Objective: The comorbidity of epilepsy and pain disorders as well as effectiveness of certain therapeutic approaches in both conditions attracted attention to epilepsy-pain interactions. This lead to the discovery of significantly shared pathophysiological mechanisms although many aspects remain largely unknown. To test the hypothesis that epilepsy may be associated with altered pain sensitivity, we analyzed interictal pain sensitivity using epilepsy prone WAG/Rij rats, a genetic model exhibiting age-related-onset absence epilepsy.