Epilepsy may cause increased pain sensitivity: Evidence from absence epileptic WAG/Rij rats


VELİOĞLU S. , GEDİKLİ Ö. , Yildirim M., AYAR A.

EPILEPSY & BEHAVIOR, vol.75, pp.146-150, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 75
  • Publication Date: 2017
  • Doi Number: 10.1016/j.yebeh.2017.07.007
  • Title of Journal : EPILEPSY & BEHAVIOR
  • Page Numbers: pp.146-150
  • Keywords: Epilepsy, Pain, Genetic absence epilepsy, WAG/Rij rats, Pain threshold, POST-ICTAL ANALGESIA, WAVE DISCHARGES, EXCITABILITY, RECEPTORS, RESPONSES, MIGRAINE, SEIZURES, MODELS, STRAIN

Abstract

Objective: The comorbidity of epilepsy and pain disorders as well as effectiveness of certain therapeutic approaches in both conditions attracted attention to epilepsy-pain interactions. This lead to the discovery of significantly shared pathophysiological mechanisms although many aspects remain largely unknown. To test the hypothesis that epilepsy may be associated with altered pain sensitivity, we analyzed interictal pain sensitivity using epilepsy prone WAG/Rij rats, a genetic model exhibiting age-related-onset absence epilepsy.