Fluorinated pyrazoline-linked axial silicon phthalocyanine, alpha (α) and beta (β) zinc phthalocyanines on photophysicochemical properties

Yalazan H., Ömeroğlu İ., Çelik G., KANTEKİN H., Durmuş M.

Inorganica Chimica Acta, vol.551, 2023 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 551
  • Publication Date: 2023
  • Doi Number: 10.1016/j.ica.2023.121480
  • Journal Name: Inorganica Chimica Acta
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex
  • Keywords: Phthalocyanine, Photodynamic therapy, Photosensitizer, Pyrazoline, Singlet oxygen, PHOTOCHEMICAL PROPERTIES, DERIVATIVES
  • Karadeniz Technical University Affiliated: Yes

Abstract

This study is focused on the photophysical and photochemical properties of silicon and zinc phthalocyanines. Fluorinated pyrazoline-linked axial silicon phthalocyanine (HY-SiPc), peripheral zinc phthalocyanine (HY-ZnPcβ), and non-peripheral zinc phthalocyanine (HY-ZnPcα) were synthesized and their structural characterizations were carried out by known Mass, NMR, UV–Vis, and FT-IR techniques. The concentration (in DMSO) and solvent effects (THF, DMSO, CHCl3, DMF, and EtOAc) of the phthalocyanine compounds were studied. The effects of the metal ion in the ring cavity (Zn2+ or Si4+) and the binding positions of the substituted group on photodynamic therapy properties were comparatively investigated. The photochemical and photophysical measurements were investigated in dimethylsulfoxide (DMSO). Examining the results, fluorinated pyrazoline-linked axial silicon phthalocyanine (HY-SiPc) showed the highest singlet oxygen production in this solvent and can be candidate a photosensitizer for PDT.