Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats
CHEMICO-BIOLOGICAL INTERACTIONS, cilt.170, sa.1, ss.40-48, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 170 Sayı: 1
- Basım Tarihi: 2007
- Doi Numarası: 10.1016/j.cbi.2007.06.040
- Dergi Adı: CHEMICO-BIOLOGICAL INTERACTIONS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.40-48
- Anahtar Kelimeler: Onosma armeniacum, ethanol, ulcer, antioxidant enzymes, rat, SUPEROXIDE-DISMUTASE INHIBITOR, GASTRIC-MUCOSAL INJURY, LIPID-PEROXIDATION, AQUEOUS EXTRACT, FREE-RADICALS, INDOMETHACIN, ANTIOXIDANT, GLUTATHIONE, DAMAGE, ACID
- Karadeniz Teknik Üniversitesi Adresli: Hayır
Özet
This study investigated the effects of Onosma armeniacum K. (Boraginaceae) root extract (AR-1) on ethanol-induced stomach ulcers, and on some oxidant and antioxidant parameters, in stomach tissue in rats. The results obtained showed that AR-1 significantly inhibited ethanol-induced ulcers at 25, 50, 100 and 200 mg/kg doses. We found that 50, 100 and 200 mg/kg doses of AR-1 inhibited ulcers more effectively than did ranitidine. AR-1 at doses of 25, 50, 100 and 200mg/kg significantly prevented the decrease in total glutathione (tGSH) level which occurs in damaged stomach tissues of rats given ethanol (control group). Only a 100 mg/kg dose of AR-1 significantly increased the glutathione S-transferase (GST) level in stomach tissue compared to the control. All doses of AR-1 except the 25 mg/kg dose eliminated the decrease in the superoxide dismutase (SOD) level in the stomach tissue of rats given ethanol. While all doses of AR-1 decreased malondialdehyde (MDA) levels significantly; all doses AR-1 except 25 mg/kg decreased myeloperoxidase (MPO) levels significantly compared to the control. The effect of AR-1 on catalase (CAT) activity was insignificant at all doses. AR-1 significantly increased nitric oxide (NO) levels at 50, 100 and 200 mg/kg doses compared to the control. Our results indicate that the protection of some antioxidant mechanisms and the inhibition of some oxidant mechanisms have a role in AR-1's antiulcer effect mechanism. (C) 2007 Elsevier Ireland Ltd. All rights reserved.