Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats

ŞAHİN, SEVİM; Gurgen, Seren; YAZAR, UĞUR; Ince, Imran; Kamasak, TÜLAY; Arslan, Elif; Durgut, Betul; DİLBER, BERİL; CANSU, ALİ

doi:10.1016/j.eplepsyres.2018.12.005

Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats

ŞAHİN S., Gurgen S. G., YAZAR U., Ince I., Kamasak T., Arslan E. A., ...Daha Fazla

EPILEPSY RESEARCH, cilt.149, ss.107-116, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 149
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.eplepsyres.2018.12.005
Dergi Adı: EPILEPSY RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.107-116
Anahtar Kelimeler: Apoptosis, Epilepsy, Hippocampus, Vitamin D, CHEMICALLY-INDUCED SEIZURES, NEUROTROPHIC FACTOR, BCL-2 FAMILY, CELL-DEATH, EXPRESSION, BRAIN, PHOSPHORYLATION, NEUROPROTECTION, DYSFUNCTION, ASTROCYTES
Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Objectives: The hippocampus is susceptible to damage in patients with epilepsy and in animals with seizures caused by excitotoxic agents. The effect of vitamin D on hippocampal apoptosis related with seizures has not been reported. However, epileptic patients have an increased risk of hypovitaminosis D which is most likely due to the effects of antiepileptic drugs. Therefore, in this study, it was aimed to evaluate the effects of vitamin D on hippocampal apoptosis related with seizures by using pentylenetetrazol (PTZ) and kainic acid (KA) in rats.