Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats

ŞAHİN, SEVİM; Gurgen, Seren; YAZAR, UĞUR; Ince, Imran; Kamasak, TÜLAY; Arslan, Elif; Durgut, Betul; DİLBER, BERİL; CANSU, ALİ

doi:10.1016/j.eplepsyres.2018.12.005

Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats

ŞAHİN S., Gurgen S. G., YAZAR U., Ince I., Kamasak T., Arslan E. A., ...More

EPILEPSY RESEARCH, vol.149, pp.107-116, 2019 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 149
Publication Date: 2019
Doi Number: 10.1016/j.eplepsyres.2018.12.005
Journal Name: EPILEPSY RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.107-116
Keywords: Apoptosis, Epilepsy, Hippocampus, Vitamin D, CHEMICALLY-INDUCED SEIZURES, NEUROTROPHIC FACTOR, BCL-2 FAMILY, CELL-DEATH, EXPRESSION, BRAIN, PHOSPHORYLATION, NEUROPROTECTION, DYSFUNCTION, ASTROCYTES
Karadeniz Technical University Affiliated: Yes

Abstract

Objectives: The hippocampus is susceptible to damage in patients with epilepsy and in animals with seizures caused by excitotoxic agents. The effect of vitamin D on hippocampal apoptosis related with seizures has not been reported. However, epileptic patients have an increased risk of hypovitaminosis D which is most likely due to the effects of antiepileptic drugs. Therefore, in this study, it was aimed to evaluate the effects of vitamin D on hippocampal apoptosis related with seizures by using pentylenetetrazol (PTZ) and kainic acid (KA) in rats.