Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats


ŞAHİN S. , Gurgen S. G. , YAZAR U. , Ince I., Kamasak T. , Arslan E. A. , ...Daha Fazla

EPILEPSY RESEARCH, cilt.149, ss.107-116, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Objectives: The hippocampus is susceptible to damage in patients with epilepsy and in animals with seizures caused by excitotoxic agents. The effect of vitamin D on hippocampal apoptosis related with seizures has not been reported. However, epileptic patients have an increased risk of hypovitaminosis D which is most likely due to the effects of antiepileptic drugs. Therefore, in this study, it was aimed to evaluate the effects of vitamin D on hippocampal apoptosis related with seizures by using pentylenetetrazol (PTZ) and kainic acid (KA) in rats.