Arterial and venous thrombosis is a prominent feature of antiphospholipid syndrome together with antiphospholipid antibodies. We report generalised thrombosis in a 28 years old male patient with antiphospholipid syndrome associated with lupus erythematosis. Firstly the patient had myocardial infarction. Eight months later he started to complain about oedema which was found to be secondary to nephrotic syndrome. In his third hospital day he developed pulmonary emboli. Tomographic angiography revealed left renal vein thrombosis, portal vein thrombosis, right renal infarct, pulmonary emboli. His tests for antinuclear antibody, anti dsDNA antibody and antiphospholipid antibody IgM were positive. After anticoagulation therapy and immunosupressive therapy he could have been disconnected from mechanical ventilator and his oedema nearly disappeared. This case clearly highlights the fact that antiphospholipid syndrome with systemic lupus erythematosus can present with myocardial infarction in young patients.