The Relationship between Metabolic Parameters, Cardiac Parameters and MIC-1/GDF15 in Obese Children


Yuca S. A. , Cimbek E. A. , Sen Y., Guevenc O., Vatansev H., Bugrul F., ...More

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, vol.125, no.2, pp.86-90, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 125 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1055/s-0042-114220
  • Title of Journal : EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
  • Page Numbers: pp.86-90
  • Keywords: obesity, MIC-1/GDF15, inflammation, cardiovascular risk management, MACROPHAGE INHIBITORY CYTOKINE-1, GROWTH-DIFFERENTIATION FACTOR-15, CHILDHOOD OBESITY, HEART, ANOREXIA, MARKER

Abstract

Objective: Childhood obesity which is a predictor of adulthood obesity is associated with type 2 diabetes, metabolic syndrome, dyslipidemia, coronary artery diseases and subclinical inflammation. Growth differentiation factor-15, also known as macrophage inhibitory cytokine-1 (MIC-1/GDF15) is a member of the transforming growth factor-super family and increases during inflammatory states. Adults with obesity have increased serum concentrations of MIC-1/GDF15.MIC-1/GDF15 is associated with cardio metabolic risk in adults.