Effects of immunonutrition on intestinal mucosal apoptosis, mucosal atrophy, and bacterial translocation in head injured rats

Ulusoy H., Usul H., Aydin S., Kaklikkaya N., Cobanoglu U., Reis A., ...More

JOURNAL OF CLINICAL NEUROSCIENCE, vol.10, no.5, pp.596-601, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 5
  • Publication Date: 2003
  • Doi Number: 10.1016/s0967-5868(03)00142-5
  • Journal Name: JOURNAL OF CLINICAL NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.596-601
  • Keywords: head injury, immunonutrition, intestinal atrophy, apoptosis, bacterial translocation, TOTAL PARENTERAL-NUTRITION, IMMUNE-ENHANCING DIET, TRAUMATIC BRAIN INJURY, PROGRAMMED CELL-DEATH, EPITHELIAL-CELLS, CRITICALLY ILL, SEPTIC COMPLICATIONS, ENTERAL DIETS, GLUTAMINE, GUT
  • Karadeniz Technical University Affiliated: Yes

Abstract

Background: Immunonutrition has been demonstrated to modulate gut function, reduce infectious complications, hospital stay, and ventilator days in the critical patients. Aim of the study: We assessed the effect of immunonutrition for the prevention of intestinal mucosal atrophy, apoptosis, and bacterial translocation in head injured rats. Methods: Thirty five rats were randomised into 5 groups. Following moderate closed head injury, in Group 1; Standard Enteral Nutrition, Group 2; Immunonutrition, Group 3; TPN, Group 4; pe. saline were applied. Group 5 was control group (chow-fed). The rats were sacrificed and segments of the ileum were removed for histologic examination, and samples of tissues taken for microbiologic evaluation. Results: Both intestinal apoptosis and mucosal atrophy were significantly lower in Group 2 and Group 5 (p < 0.008). Bacterial translocation was significantly lower in Group 2 than Group 1 (p < 0.008). Conclusion: The enteral immunonutrition prevents intestinal barrier function in brain injured rats. (C) 2003 Elsevier Science Ltd. All rights reserved.