Effects of immunonutrition on intestinal mucosal apoptosis, mucosal atrophy, and bacterial translocation in head injured rats
JOURNAL OF CLINICAL NEUROSCIENCE, vol.10, no.5, pp.596-601, 2003 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 10 Issue: 5
- Publication Date: 2003
- Doi Number: 10.1016/s0967-5868(03)00142-5
- Journal Name: JOURNAL OF CLINICAL NEUROSCIENCE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.596-601
- Keywords: head injury, immunonutrition, intestinal atrophy, apoptosis, bacterial translocation, TOTAL PARENTERAL-NUTRITION, IMMUNE-ENHANCING DIET, TRAUMATIC BRAIN INJURY, PROGRAMMED CELL-DEATH, EPITHELIAL-CELLS, CRITICALLY ILL, SEPTIC COMPLICATIONS, ENTERAL DIETS, GLUTAMINE, GUT
- Karadeniz Technical University Affiliated: Yes
Abstract
Background: Immunonutrition has been demonstrated to modulate gut function, reduce infectious complications, hospital stay, and ventilator days in the critical patients. Aim of the study: We assessed the effect of immunonutrition for the prevention of intestinal mucosal atrophy, apoptosis, and bacterial translocation in head injured rats. Methods: Thirty five rats were randomised into 5 groups. Following moderate closed head injury, in Group 1; Standard Enteral Nutrition, Group 2; Immunonutrition, Group 3; TPN, Group 4; pe. saline were applied. Group 5 was control group (chow-fed). The rats were sacrificed and segments of the ileum were removed for histologic examination, and samples of tissues taken for microbiologic evaluation. Results: Both intestinal apoptosis and mucosal atrophy were significantly lower in Group 2 and Group 5 (p < 0.008). Bacterial translocation was significantly lower in Group 2 than Group 1 (p < 0.008). Conclusion: The enteral immunonutrition prevents intestinal barrier function in brain injured rats. (C) 2003 Elsevier Science Ltd. All rights reserved.