Effects of immunonutrition on intestinal mucosal apoptosis, mucosal atrophy, and bacterial translocation in head injured rats

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Atıf İçin Kopyala

Ulusoy H., Usul H., Aydin S., Kaklikkaya N., Cobanoglu U., Reis A., ...Daha Fazla

JOURNAL OF CLINICAL NEUROSCIENCE, cilt.10, sa.5, ss.596-601, 2003 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 10 Sayı: 5
• Basım Tarihi: 2003
• Doi Numarası: 10.1016/s0967-5868(03)00142-5
• Dergi Adı: JOURNAL OF CLINICAL NEUROSCIENCE
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.596-601
• Anahtar Kelimeler: head injury, immunonutrition, intestinal atrophy, apoptosis, bacterial translocation, TOTAL PARENTERAL-NUTRITION, IMMUNE-ENHANCING DIET, TRAUMATIC BRAIN INJURY, PROGRAMMED CELL-DEATH, EPITHELIAL-CELLS, CRITICALLY ILL, SEPTIC COMPLICATIONS, ENTERAL DIETS, GLUTAMINE, GUT
• Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background: Immunonutrition has been demonstrated to modulate gut function, reduce infectious complications, hospital stay, and ventilator days in the critical patients. Aim of the study: We assessed the effect of immunonutrition for the prevention of intestinal mucosal atrophy, apoptosis, and bacterial translocation in head injured rats. Methods: Thirty five rats were randomised into 5 groups. Following moderate closed head injury, in Group 1; Standard Enteral Nutrition, Group 2; Immunonutrition, Group 3; TPN, Group 4; pe. saline were applied. Group 5 was control group (chow-fed). The rats were sacrificed and segments of the ileum were removed for histologic examination, and samples of tissues taken for microbiologic evaluation. Results: Both intestinal apoptosis and mucosal atrophy were significantly lower in Group 2 and Group 5 (p < 0.008). Bacterial translocation was significantly lower in Group 2 than Group 1 (p < 0.008). Conclusion: The enteral immunonutrition prevents intestinal barrier function in brain injured rats. (C) 2003 Elsevier Science Ltd. All rights reserved.