Radiotherapy Induces Development of Fragmented QRS in Patients with Breast Cancer

ADAR A., CANYILMAZ E., Kiris A., Ilter A., Serdar L., Memis Y., ...Daha Fazla

BREAST CARE, cilt.10, sa.4, ss.277-280, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1159/000431030
  • Dergi Adı: BREAST CARE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.277-280
  • Anahtar Kelimeler: Fragmented QRS, Radiotherapy, Breast cancer, CARDIAC MAGNETIC-RESONANCE, HEART-DISEASE, CARDIOVASCULAR TOXICITIES, 12-LEAD ECG, FIBROSIS, COMPLEX, EPIDEMIOLOGY, MORTALITY, SURVIVAL, THERAPY
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background: Myocardial fibrosis is a well-known side effect of radiotherapy. Fragmented QRS (fQRS) has been shown to be a marker of myocardial fibrosis. We postulated that radiotherapy induces development of fQRS in breast cancer patients. Patients and Methods: Breast cancer patients receiving locoregional radiotherapy were enrolled. Patients who had fQRS on electrocardiography (ECG) before radiotherapy were excluded. All patients were revaluated for the development of fQRS at 1-year follow-up. An age-matched healthy group served as controls. Results: A total of 52 breast cancer patients receiving locoregional radiotherapy were included (median age 49 years, interquartile range (IQR) 13). Of these, 19 (37%) had developed fQRS at 1-year follow-up. Compared with the control group, prevalence of fQRS was significantly higher in the irradiated group (37 vs. 12%; p < 0.002). Median total cardiac radiation dose was significantly higher in patients who had developed fQRS (5 Gy, IQR 5.2 vs. 1.7 Gy, IQR 4.4; p = 0.003). Cardiac radiation dose, entered either as a continuous variable (odds ratio (OR) 1.35, 95% confidence interval (CI) 104-1.74) or as a dichotomized variable (>= 2.2 Gy, OR 6.48, 95% CI 1.47-28.61), was independently associated with the development of fQRS at 1-year follow-up. Conclusion: Radiotherapy for breast cancer induces development of fQRS on ECG. Cardiac radiation dose is independently associated with the development of fQRS.