Akademik Veri Yönetim Sistemi
Studies in Natural Products Chemistry, cilt.82, ss.55-112, 2024 (Scopus)
Bioactive natural hydroxyapatite (BNHA) biocomposites are commonly used in various biomedical applications due to their excellent biocompatibility. However, their ability to kill bacteria is limited. To enhance their antibacterial properties, researchers have investigated different techniques, such as surface modifications, integrating antimicrobial agents, and using nanotechnology methods. To enhance the antibacterial properties of BNHA biocomposites, surface modification is a simple and effective technique. Several methods have been developed, including coating the BNHA surface with silver nanoparticles that have potent bactericidal activity. The silver nanoparticles can be deposited on the surface using various methods, such as sol-gel, hydrothermal, and electrochemical deposition. The silver-doped BNHA nanorods have been shown to exhibit excellent antibacterial effects against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Another approach to improving the antibacterial effect of BNHA biocomposites is by incorporating antimicrobial agents, such as antibiotics or antimicrobial peptides. The antimicrobial agents can be loaded onto the BNHA by various methods, such as physical adsorption, covalent binding, and encapsulation. For example, vancomycin-loaded BNHA nanorods have demonstrated a sustained release of the drug and excellent antibacterial activity against S. aureus and E. coli. Nanotechnology approaches have also been explored to enhance the antibacterial effect of BNHA biocomposites. The nanotechnology approaches involve the incorporation of nanoparticles or nanomaterials, such as graphene oxide (GO), silver nanoparticles, and zinc oxide, into the BNHA. For instance, a BNHA-GO nanobiocomposites scaffold has exhibited excellent antibacterial activity against E. coli and S. aureus. Similarly, silver nanoparticle-decorated BNHA nanorods have shown a potent bactericidal effect against E. coli and S. aureus. In conclusion, different approaches have been explored to improve the antibacterial effect of BNHA biocomposites, including surface modifications, the incorporation of antimicrobial agents, and nanotechnology approaches. The purpose of this chapter is to summarize the approaches to improving the antibacterial effect of BNHA-based biocomposites. In addition, the results of research on improving the antibacterial effect of BNHA-based biocomposites were discussed with the support of the literature.