Effects of resveratrol on methotrexate-induced intestinal injury

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Yulug E., Turedi S., Alver A., Turedi S., Kahraman C.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.116, no.11, pp.676-680, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 116 Issue: 11
  • Publication Date: 2015
  • Doi Number: 10.4149/bll_2015_132
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.676-680
  • Keywords: methotrexate, resveratrol, rat, small intestine, oxidative stress, OXIDATIVE STRESS, ISCHEMIA/REPERFUSION INJURY, ANTIOXIDANT, PROTECTS, DAMAGE, MUCOSITIS, TOXICITY, AGENT, RATS
  • Karadeniz Technical University Affiliated: Yes

Abstract

BACKGROUND: Methotrexate (MTX) is an anticancer drug. Many studies have reported that MTX causes oxidative stress-associated damage in the small intestine. The purpose of this study was to investigate the possible protective effect of resveratrol (RES), an antioxidant, against MIX-induced damage in the small intestine.