DIRECT VASCULAR SMOOTH-MUSCLE CONTRACTILE EFFECT OF CYCLOSPORINE-A AND ITS VEHICLE IN RABBIT ISOLATED ARTERIES

YARIS E., TUNCER M., KAYAALP S., ILHAN M.

ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, cilt.327, sa.2, ss.166-174, 1994 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 327 Sayı: 2
  • Basım Tarihi: 1994
  • Dergi Adı: ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.166-174
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Cyclosporin A is a widely used immunosuppressant agent which has direct vascular effects such as contraction of the arterial smooth muscle and potentiation of other vasoconstrictor agents. In rabbit isolated arterial segments, the contractile effects of a cyclosporin A preparation (Sandimmun(R); 10(-6) M) and its solvent (Cremophor-EL) were investigated. Both caused an increase in the basal tension of arterial segments after an incubation period of 1 hour. Several substances were tested to antagonize the contractile activity of the cyclosporin A preparation and its solvent. Prednisolone and quinacrine (phospholipase A2 inhibitors), indomethacin (cyclooxygenase inhibitor), verapamil (calcium antagonist), phentolamine (alpha-adrenoceptor blocker), captopril (angiotensin-converting enzyme inhibitor) and prazosin (alpha1-adrenoceptor-blocking agent) decreased the contractile responses to the cyclosporin A preparation and its solvent in a comparable manner. These findings indicate that the solvent of the cyclosporin A preparation is responsible for the contractile effect of this latter preparation and that this contractile activity cannot be explained by a single mechanism.