Microwave-Assisted Synthesis, Antioxidant, and Antimicrobial Evaluation of Piperazine-Azole-Fluoroquinolone Based 1,2,4-Triazole Derivatives


OZDEMIR S. B. , DEMİRBAŞ N., DEMİRBAŞ A., AYAZ F. A. , ÇOLAK N.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.55, no.12, pp.2744-2759, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 12
  • Publication Date: 2018
  • Doi Number: 10.1002/jhet.3336
  • Journal Name: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2744-2759
  • Karadeniz Technical University Affiliated: Yes

Abstract

Azole derivatives (10a-f) obtained starting from 1-(4-fluorohenyl)piperazine were converted to the corresponding Mannich bases (7a-d, 12a,b, and 16a,b) containing beta-lactame or flouroquinolone core via a one-pot three-component reaction. The synthesis of conazole analogues was carried out starting from triazole by three steps. Reactions were carried out under conventional-mediated and microwave-mediated conditions. All the newly synthesized compounds were screened for their antimicrobial, antioxidant activity, and most of them displayed good-moderate activity.