Detection of linear IgE deposits in bullous pemphigoid and mucous membrane pemphigoid: a useful clue for diagnosis


YAYLI S. , Pelivani N., Beltraminelli H., Wirthmueller U., Beleznay Z., Horn M., ...Daha Fazla

BRITISH JOURNAL OF DERMATOLOGY, cilt.165, ss.1133-1137, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 165 Konu: 5
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1111/j.1365-2133.2011.10481.x
  • Dergi Adı: BRITISH JOURNAL OF DERMATOLOGY
  • Sayfa Sayıları: ss.1133-1137

Özet

Background Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease of the skin associated with IgG autoantibodies to BP180 and BP230, while mucous membrane pemphigoid (MMP) comprises a heterogeneous group of autoimmune blistering diseases characterized by a predominant mucous membrane involvement and scarring tendency associated with an autoantibody response to various autoantigens, including BP180. While the pathogenicity of IgG autoantibodies to BP180 has been demonstrated in BP, the role of IgE autoantibodies in mediating tissue damage in BP and MMP is unclear.