Detection of linear IgE deposits in bullous pemphigoid and mucous membrane pemphigoid: a useful clue for diagnosis


YAYLI S. , Pelivani N., Beltraminelli H., Wirthmueller U., Beleznay Z., Horn M., ...More

BRITISH JOURNAL OF DERMATOLOGY, vol.165, no.5, pp.1133-1137, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 165 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.1111/j.1365-2133.2011.10481.x
  • Title of Journal : BRITISH JOURNAL OF DERMATOLOGY
  • Page Numbers: pp.1133-1137

Abstract

Background Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease of the skin associated with IgG autoantibodies to BP180 and BP230, while mucous membrane pemphigoid (MMP) comprises a heterogeneous group of autoimmune blistering diseases characterized by a predominant mucous membrane involvement and scarring tendency associated with an autoantibody response to various autoantigens, including BP180. While the pathogenicity of IgG autoantibodies to BP180 has been demonstrated in BP, the role of IgE autoantibodies in mediating tissue damage in BP and MMP is unclear.