Detection of linear IgE deposits in bullous pemphigoid and mucous membrane pemphigoid: a useful clue for diagnosis

YAYLI S., Pelivani N., Beltraminelli H., Wirthmueller U., Beleznay Z., Horn M., ...Daha Fazla

BRITISH JOURNAL OF DERMATOLOGY, cilt.165, sa.5, ss.1133-1137, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 165 Sayı: 5
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1111/j.1365-2133.2011.10481.x
  • Dergi Adı: BRITISH JOURNAL OF DERMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1133-1137
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease of the skin associated with IgG autoantibodies to BP180 and BP230, while mucous membrane pemphigoid (MMP) comprises a heterogeneous group of autoimmune blistering diseases characterized by a predominant mucous membrane involvement and scarring tendency associated with an autoantibody response to various autoantigens, including BP180. While the pathogenicity of IgG autoantibodies to BP180 has been demonstrated in BP, the role of IgE autoantibodies in mediating tissue damage in BP and MMP is unclear.