Increased salivary level of 8-hydroxydeoxyguanosine is a marker of premature oxidative mitochondrial DNA damage in gingival tissue of patients with periodontitis


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ÇANAKÇI C. F. , Canakci V., TATAR A., Eltas A., Sezer U., Cicek Y., ...Daha Fazla

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, cilt.57, sa.3, ss.205-211, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Konu: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s00005-009-0026-9
  • Dergi Adı: ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
  • Sayfa Sayıları: ss.205-211

Özet

Introduction: Oxidative stress may contribute to the pathogenesis of periodontitis. However, the detailed molecular mechanism remains unclear. Both 8-hydroxydeoxyguanosine (8-OHdG) and mitochondrial DNA (mtDNA) deletion have been reported as early oxidative DNA damage markers. In this study, 8-OHdG levels in saliva and mtDNA deletions in gingival tissue of patients with chronic periodontitis (CP) were evaluated.