Increased salivary level of 8-hydroxydeoxyguanosine is a marker of premature oxidative mitochondrial DNA damage in gingival tissue of patients with periodontitis


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ÇANAKÇI C. F. , Canakci V., TATAR A., Eltas A., Sezer U., Cicek Y., ...More

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, vol.57, no.3, pp.205-211, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1007/s00005-009-0026-9
  • Title of Journal : ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
  • Page Numbers: pp.205-211

Abstract

Introduction: Oxidative stress may contribute to the pathogenesis of periodontitis. However, the detailed molecular mechanism remains unclear. Both 8-hydroxydeoxyguanosine (8-OHdG) and mitochondrial DNA (mtDNA) deletion have been reported as early oxidative DNA damage markers. In this study, 8-OHdG levels in saliva and mtDNA deletions in gingival tissue of patients with chronic periodontitis (CP) were evaluated.