Increased salivary level of 8-hydroxydeoxyguanosine is a marker of premature oxidative mitochondrial DNA damage in gingival tissue of patients with periodontitis

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ÇANAKÇI C. F., Canakci V., TATAR A., Eltas A., Sezer U., Cicek Y., ...More

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, vol.57, no.3, pp.205-211, 2009 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 57 Issue: 3
• Publication Date: 2009
• Doi Number: 10.1007/s00005-009-0026-9
• Journal Name: ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.205-211
• Open Archive Collection: AVESIS Open Access Collection
• Karadeniz Technical University Affiliated: Yes

Abstract

Introduction: Oxidative stress may contribute to the pathogenesis of periodontitis. However, the detailed molecular mechanism remains unclear. Both 8-hydroxydeoxyguanosine (8-OHdG) and mitochondrial DNA (mtDNA) deletion have been reported as early oxidative DNA damage markers. In this study, 8-OHdG levels in saliva and mtDNA deletions in gingival tissue of patients with chronic periodontitis (CP) were evaluated.