Increased salivary level of 8-hydroxydeoxyguanosine is a marker of premature oxidative mitochondrial DNA damage in gingival tissue of patients with periodontitis

ÇANAKÇI, Cenk; Canakci, Varol; TATAR, Abdulgani; Eltas, Abubekir; Sezer, Ufuk; Cicek, Yasin; Oztas, Sitki

doi:10.1007/s00005-009-0026-9

Increased salivary level of 8-hydroxydeoxyguanosine is a marker of premature oxidative mitochondrial DNA damage in gingival tissue of patients with periodontitis

ÇANAKÇI C. F., Canakci V., TATAR A., Eltas A., Sezer U., Cicek Y., ...Daha Fazla

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, cilt.57, sa.3, ss.205-211, 2009 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 57 Sayı: 3
Basım Tarihi: 2009
Doi Numarası: 10.1007/s00005-009-0026-9
Dergi Adı: ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.205-211
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Introduction: Oxidative stress may contribute to the pathogenesis of periodontitis. However, the detailed molecular mechanism remains unclear. Both 8-hydroxydeoxyguanosine (8-OHdG) and mitochondrial DNA (mtDNA) deletion have been reported as early oxidative DNA damage markers. In this study, 8-OHdG levels in saliva and mtDNA deletions in gingival tissue of patients with chronic periodontitis (CP) were evaluated.